An investigation into applicability of sodium carboxymethylcellulose and sodium alginate as film-forming agents for semi-solid 3D printing

Abstract

Semi-solid 3D printing technology has gained increased interest in the pharmaceutical field as it enables on-demand fabrication of personalized dosage forms. Orodispersible films (ODFs) are good candidates for 3D printing because of their relatively simple formulation, flexible dosing, and suitability for administration in different populations. The aim of this work was to investigate the applicability of sodium carboxymethyl cellulose and sodium alginate as film-forming agents for 3D printed ODFs incorporating amlodipine or warfarin as selected model active pharmaceutical ingredients (API).