COMPARATIVE ASSESSMENT OF CATALASE LEVELS IN PERI-IMPLANT HEALTH AND DISEASE

Q3 Dentistry Journal of long-term effects of medical implants Pub Date : 2023-01-01 DOI:10.1615/jlongtermeffmedimplants.2023047580

Rithanya M, Arvina Rajasekar

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Abstract

Background: Peri-implant disease pathogenesis is similar to periodontal disease pathogenesis resulting in production of pro-inflammatory mediators. These mediators alter the redox balance leading to decrease in antioxidants, among which catalase is one of the enzymatic antioxidants. The aim of the study was to compare the levels of catalase in peri-implant health and disease. Materials and Methods: The present observational study was carried out from June 2022 to December 2022 in the Department of Implantology, Saveetha Dental College and Hospitals, Chennai, India. A total of 60 patients with peri-implant health (Group 1; n=20), peri-implant mucositis (Group 2; n=20) and peri-implantitis (Group 3; n=20) were enrolled. Unstimulated salivary samples were collected and subjected to ELISA for catalase analysis. Catalase levels were then compared between the groups using ANOVA. Results: The mean catalase level in peri-implant health, peri-implant mucositis, peri-implantitis were 25.07±0.44 U/mL, 18.56±0.65 U/mL and 11.25±0.76 U/mL respectively. The difference between the three groups were statistically significant (p<0.05). Conclusion: Catalase level decreases with severity of peri-implant diseases. Therefore, catalase can be used as a diagnostic marker for peri-implant diseases.

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种植体周围健康和疾病中过氧化氢酶水平的比较评估

背景:种植体周围疾病的发病机制与牙周病的发病机制相似，导致促炎介质的产生。这些介质改变氧化还原平衡，导致抗氧化剂减少，其中过氧化氢酶是酶促抗氧化剂之一。该研究的目的是比较种植体周围健康和疾病中过氧化氢酶的水平。材料与方法:本观察性研究于2022年6月至2022年12月在印度金奈Saveetha牙科学院和医院种植科进行。共60例患者种植体周围健康(第一组;n=20)，种植体周围粘膜炎(第二组;n=20)和种植体周围炎(第三组;N =20)。采集未刺激唾液标本，采用酶联免疫吸附试验(ELISA)进行过氧化氢酶分析。然后用方差分析比较各组间过氧化氢酶水平。结果:种植体周围健康组、种植体周围黏膜炎组、种植体周围炎组过氧化氢酶平均水平分别为25.07±0.44 U/mL、18.56±0.65 U/mL和11.25±0.76 U/mL。三组间差异均有统计学意义(p<0.05)。结论:过氧化氢酶水平随种植体周围疾病的严重程度而降低。因此，过氧化氢酶可作为种植体周围疾病的诊断标志物。

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Journal of long-term effects of medical implants Dentistry-Dentistry (all)

CiteScore

1.20

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0.00%

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期刊介绍： MEDICAL IMPLANTS are being used in every organ of the human body. Ideally, medical implants must have biomechanical properties comparable to those of autogenous tissues without any adverse effects. In each anatomic site, studies of the long-term effects of medical implants must be undertaken to determine accurately the safety and performance of the implants. Today, implant surgery has become an interdisciplinary undertaking involving a number of skilled and gifted specialists. For example, successful cochlear implants will involve audiologists, audiological physicians, speech and language therapists, otolaryngologists, nurses, neuro-otologists, teachers of the deaf, hearing therapists, cochlear implant manufacturers, and others involved with hearing-impaired and deaf individuals.