The nasal route, advanced drug delivery systems and evaluation: a review

IF 0.2 Q4 RESPIRATORY SYSTEM Egyptian Journal of Chest Diseases and Tuberculosis Pub Date : 2023-01-01 DOI:10.4103/ecdt.ecdt_122_22
Kaneriya Rutvik, Patel Meshva, Patel Dinal, Dholakia Mansi
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Abstract

Abstract Nasal drug delivery is a well-known alternative to oral and parenteral drug delivery systems. Protein, peptides, hormones, and vaccines are the sensitive molecules for the oral route; hence those can be reached via nasal delivery. The nasal way has several advantages: higher permeability, more vasculature, less contact with enzymes due to less nasal space, and no hepatic first-pass metabolism. Therefore, it is a suitable route for sensitive drug molecules. Different applicators can deliver solid, liquid, and semisolid formulations for treating various diseases. The present review considers a brief introduction to the nasal route and problems associated with the nasal course for drug delivery, conventional and novel formulations, their applications, and evaluation parameters. Moreover, some of the marketed formulations for the nasal route of drug delivery systems and patented technologies are tabulated by reviewing the previous and updated literature.
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鼻途径、先进给药系统及其评价综述
鼻给药是一种众所周知的替代口服和肠外给药系统。蛋白质、多肽、激素和疫苗是口服途径的敏感分子;因此,这些可以通过鼻腔输送。鼻腔方式有几个优点:渗透性高,血管多,由于鼻腔空间小,与酶接触少,没有肝脏第一次代谢。因此,它是敏感药物分子的合适途径。不同的涂抹器可以提供用于治疗各种疾病的固体、液体和半固体制剂。本文简要介绍了药物的鼻腔给药途径和相关问题、传统和新型制剂、它们的应用和评价参数。此外,通过回顾以前和更新的文献,列出了一些已上市的鼻腔给药系统配方和专利技术。
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来源期刊
自引率
0.00%
发文量
46
审稿时长
22 weeks
期刊介绍: The journal will cover technical and clinical studies related to health, ethical and social issues in field of The Egyptian Journal of Chest Diseases and Tuberculosis aims to publish and inform readers and all chest physicians of the progress in medical research concerning all aspect of chest diseases. Publications include original articles review articles, editorials, case studies and reports which are relevant to chest diseases. The Journal also aims to highlight recent updates in chest medicine. . Articles with clinical interest and implications will be given preference.
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