The nasal route, advanced drug delivery systems and evaluation: a review

IF 0.2 Q4 RESPIRATORY SYSTEM Egyptian Journal of Chest Diseases and Tuberculosis Pub Date : 2023-01-01 DOI:10.4103/ecdt.ecdt_122_22
Kaneriya Rutvik, Patel Meshva, Patel Dinal, Dholakia Mansi
{"title":"The nasal route, advanced drug delivery systems and evaluation: a review","authors":"Kaneriya Rutvik, Patel Meshva, Patel Dinal, Dholakia Mansi","doi":"10.4103/ecdt.ecdt_122_22","DOIUrl":null,"url":null,"abstract":"Abstract Nasal drug delivery is a well-known alternative to oral and parenteral drug delivery systems. Protein, peptides, hormones, and vaccines are the sensitive molecules for the oral route; hence those can be reached via nasal delivery. The nasal way has several advantages: higher permeability, more vasculature, less contact with enzymes due to less nasal space, and no hepatic first-pass metabolism. Therefore, it is a suitable route for sensitive drug molecules. Different applicators can deliver solid, liquid, and semisolid formulations for treating various diseases. The present review considers a brief introduction to the nasal route and problems associated with the nasal course for drug delivery, conventional and novel formulations, their applications, and evaluation parameters. Moreover, some of the marketed formulations for the nasal route of drug delivery systems and patented technologies are tabulated by reviewing the previous and updated literature.","PeriodicalId":46359,"journal":{"name":"Egyptian Journal of Chest Diseases and Tuberculosis","volume":"21 1","pages":"0"},"PeriodicalIF":0.2000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Egyptian Journal of Chest Diseases and Tuberculosis","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/ecdt.ecdt_122_22","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
引用次数: 0

Abstract

Abstract Nasal drug delivery is a well-known alternative to oral and parenteral drug delivery systems. Protein, peptides, hormones, and vaccines are the sensitive molecules for the oral route; hence those can be reached via nasal delivery. The nasal way has several advantages: higher permeability, more vasculature, less contact with enzymes due to less nasal space, and no hepatic first-pass metabolism. Therefore, it is a suitable route for sensitive drug molecules. Different applicators can deliver solid, liquid, and semisolid formulations for treating various diseases. The present review considers a brief introduction to the nasal route and problems associated with the nasal course for drug delivery, conventional and novel formulations, their applications, and evaluation parameters. Moreover, some of the marketed formulations for the nasal route of drug delivery systems and patented technologies are tabulated by reviewing the previous and updated literature.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
鼻途径、先进给药系统及其评价综述
鼻给药是一种众所周知的替代口服和肠外给药系统。蛋白质、多肽、激素和疫苗是口服途径的敏感分子;因此,这些可以通过鼻腔输送。鼻腔方式有几个优点:渗透性高,血管多,由于鼻腔空间小,与酶接触少,没有肝脏第一次代谢。因此,它是敏感药物分子的合适途径。不同的涂抹器可以提供用于治疗各种疾病的固体、液体和半固体制剂。本文简要介绍了药物的鼻腔给药途径和相关问题、传统和新型制剂、它们的应用和评价参数。此外,通过回顾以前和更新的文献,列出了一些已上市的鼻腔给药系统配方和专利技术。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
46
审稿时长
22 weeks
期刊介绍: The journal will cover technical and clinical studies related to health, ethical and social issues in field of The Egyptian Journal of Chest Diseases and Tuberculosis aims to publish and inform readers and all chest physicians of the progress in medical research concerning all aspect of chest diseases. Publications include original articles review articles, editorials, case studies and reports which are relevant to chest diseases. The Journal also aims to highlight recent updates in chest medicine. . Articles with clinical interest and implications will be given preference.
期刊最新文献
Escalation to invasive mechanical ventilation in noninvasive ventilation failure: some insights about methodology Effect of physiotherapy and its frequency on the outcome of COVID-19 patients regarding acute care setting at isolation unit of Ain Shams University Role of interleukin-6 in coronavirus disease 2019 pneumonia: sensitive marker of inflammation, a predictor of ventilatory support and early marker of post-coronavirus disease lung fibrosis. A single center experience Diagnostic performance of transthoracic ultrasound in patients with pulmonary embolism Proportion and prognosis of ICU-admitted coronavirus disease 2019-infected patients in relation to all hospitalized cases in Abbasia Chest Hospital, Cairo
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1