A pan-metazoan view of germline-soma distinction challenges our understanding of how the metazoan germline evolves

IF 3.4 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Current Opinion in Systems Biology Pub Date : 2023-12-01 DOI:10.1016/j.coisb.2023.100486
Dominic K. Devlin , Austen R.D. Ganley , Nobuto Takeuchi
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Abstract

A germline-soma distinction — irreversible differentiation from reproductive germline cells to sterile somatic cells — is a landmark of cellular cooperation in metazoans. Traditionally, this distinction was considered a property of only some metazoan taxa, such as vertebrates and insects. However, recent studies on a number of other metazoan taxa are challenging this traditional perspective, suggesting that a germline-soma distinction is widespread among metazoans. Here, we review recent molecular and cellular evidence supporting this suggestion and emphasise the difference between germline-soma distinction and germline segregation. We also outline the considerable diversity among metazoans in germline specification, segregation and regeneration. We finish by discussing how evolutionary explanations for this diversity can be investigated by harnessing theoretical modelling approaches.

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泛后生动物对生殖细胞-体细胞区分的观点挑战了我们对后生动物生殖细胞如何进化的理解
生殖细胞-体细胞的分化——从生殖生殖细胞到不育体细胞的不可逆分化——是后生动物细胞合作的一个里程碑。传统上,这种区别被认为是一些后生动物分类群的特性,比如脊椎动物和昆虫。然而,最近对许多其他后生动物分类群的研究正在挑战这一传统观点,表明生殖-体细胞区分在后生动物中很普遍。在这里,我们回顾了最近支持这一观点的分子和细胞证据,并强调了种系-体细胞区分和种系分离之间的区别。我们还概述了后生动物在种系规范、分离和再生方面的相当大的多样性。最后,我们将讨论如何利用理论建模方法来研究这种多样性的进化解释。
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来源期刊
Current Opinion in Systems Biology
Current Opinion in Systems Biology Mathematics-Applied Mathematics
CiteScore
7.10
自引率
2.70%
发文量
20
期刊介绍: Current Opinion in Systems Biology is a new systematic review journal that aims to provide specialists with a unique and educational platform to keep up-to-date with the expanding volume of information published in the field of Systems Biology. It publishes polished, concise and timely systematic reviews and opinion articles. In addition to describing recent trends, the authors are encouraged to give their subjective opinion on the topics discussed. As this is such a broad discipline, we have determined themed sections each of which is reviewed once a year. The following areas will be covered by Current Opinion in Systems Biology: -Genomics and Epigenomics -Gene Regulation -Metabolic Networks -Cancer and Systemic Diseases -Mathematical Modelling -Big Data Acquisition and Analysis -Systems Pharmacology and Physiology -Synthetic Biology -Stem Cells, Development, and Differentiation -Systems Biology of Mold Organisms -Systems Immunology and Host-Pathogen Interaction -Systems Ecology and Evolution
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