Mesoporous bioactive glass nanoparticles with biomineralization activity for surgical hemorrhage control

IF 7.4 3区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Science and Technology of Advanced Materials Pub Date : 2023-11-06 DOI:10.1080/14686996.2023.2279030

Shengyu Li, Xijin Wu, Jianglin Chen, Jinwei Wang, Lihong Gong, Jianyu Ni, Saifei Xi, Hong Zhang, Huiying Fu, Qiyang Shou

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Abstract

Bioactive glass nanoparticles (BGNs) are good bioactive materials for clinical treatment because of their unique composition and silica-oxygen network structure. Herein, we designed and reported a monodisperse mesoporous bioactive glass nanoparticles with biomineralization activity for surgical hemorrhage control. The results indicated that the BGNs have excellent biomineralization ability. In vivo and in vitro hemostasis studies suggested that BGNs has superior hemostatic properties to GZ (gauze) and GS (commercial gelatin sponge) and validated in vitro thrombosis, platelet adhesion, cytocompatibility and blood compatibility. The particles activated both endogenous and exogenous physiological coagulation pathways and could activate platelets and release Ca2+ to participate in the clotting pathway. Besides, the BGNs have good biocompatibility in vivo. These findings demonstrated the potential of small diameter mesoporous bioactive glass nanoparticles are likely useful for bleeding control as potential hemostatic agents.

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具有生物矿化活性的介孔生物活性玻璃纳米颗粒用于外科出血控制

生物活性玻璃纳米颗粒(BGNs)由于其独特的组成和硅氧网络结构，是临床治疗中良好的生物活性材料。在此，我们设计并报道了一种具有生物矿化活性的单分散介孔生物活性玻璃纳米颗粒，用于外科出血控制。结果表明，BGNs具有良好的生物矿化能力。体内和体外止血研究表明，BGNs具有优于GZ(纱布)和GS(商用明胶海绵)的止血性能，并在体外血栓形成、血小板粘附、细胞相容性和血液相容性方面得到验证。该颗粒激活内源性和外源性生理凝血途径，可激活血小板并释放Ca2+参与凝血途径。此外，bgn具有良好的体内生物相容性。这些发现证明了小直径介孔生物活性玻璃纳米颗粒作为潜在的止血剂可能用于出血控制。

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来源期刊

Science and Technology of Advanced Materials 工程技术-材料科学：综合

CiteScore

10.60

自引率

3.60%

发文量

审稿时长

4.8 months

期刊介绍： Science and Technology of Advanced Materials (STAM) is a leading open access, international journal for outstanding research articles across all aspects of materials science. Our audience is the international community across the disciplines of materials science, physics, chemistry, biology as well as engineering. The journal covers a broad spectrum of topics including functional and structural materials, synthesis and processing, theoretical analyses, characterization and properties of materials. Emphasis is placed on the interdisciplinary nature of materials science and issues at the forefront of the field, such as energy and environmental issues, as well as medical and bioengineering applications. Of particular interest are research papers on the following topics: Materials informatics and materials genomics Materials for 3D printing and additive manufacturing Nanostructured/nanoscale materials and nanodevices Bio-inspired, biomedical, and biological materials; nanomedicine, and novel technologies for clinical and medical applications Materials for energy and environment, next-generation photovoltaics, and green technologies Advanced structural materials, materials for extreme conditions.