A comprehensive review on metallodrugs in breast cancer treatment

Abstract

It is shocking that breast cancer (BC) now outnumbers lung cancer in terms of global cancer diagnoses. Being deadly to some extent, such a disease’s treatment is crucial. Surgery, radiation therapy, chemotherapy, hormonal therapy, and targeted therapy are just a few of the treatment options available for this condition. By using ligand substitution to alter the current chemical structure or by creating an entirely new element with a higher safety and cytotoxic profile, the metallodrugs are created. Due to their tempting treatment against cancer and their capacity to produce reactive oxygen species (ROS) and reactive nitrogen species (RNS), which cause oxidative damage and cellular death, metals are extremely efficient in the fight against cancer. The whole list of recently found complexes (in vivo/vitro), their mode of action against the tumour, and the mechanical information gathered by various scientists have all been discussed in the following paragraphs. This review highlights the research that has been conducted over the past 22 years by many experts and provide comprehensive information regarding the use of metals as a medicine for the treatment of BC. Also, this review covers a variety of prospective metal therapies down the line with their success stories.