Would It be Possible for a SARS-CoV-2 Infection to Affect the Male Reproductive System?

Abstract

The male reproductive system may be affected by the systemic infections of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The precise mechanisms of male reproductive impairment are not well known. There are two possible mechanisms for the effect of SARS-CoV-2 on the male reproductive system either directly through the impact of the angiotensin-converting enzyme 2 (ACE2) receptor on testicular tissue or indirectly through the effect of the secondary autoimmune response on testicular functions. The second mechanism is more likely. Extensive studies need to be conducted on the impact of SARS-CoV-2 on the functional characteristics of sperm and the results of natural fertilization or assisted reproductive technology.