The Efficacy, Safety, and Recurrence Rate of Diphenylcyclopropenone Topical Immunotherapy for Alopecia Areata: A Systemic Review and Meta-Analysis

IF 3.7 4区医学 Q1 DERMATOLOGY Dermatologic Therapy Pub Date : 2023-10-03 DOI:10.1155/2023/6073889

Jiaping Zhu, Rui Qiao, Yufen Li, Xuemei Lan, Xiangdong Gong, Yiqun Jiang

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Abstract

Background and Objective. Diphenylcyclopropenone topical immunotherapy is widely used in the treatment of alopecia areata. However, previous studies have shown significant differences in its efficacy. We conducted this systemic review and meta-analysis to investigate the efficacy, safety, and recurrence rate of diphenylcyclopropenone topical immunotherapy for alopecia areata. Methods. Literatures related to diphenylcyclopropenone topical immunotherapy for alopecia areata between January 1st, 2002, and July 2nd, 2022, were searched in the following databases: PubMed, Embase, Cochrane Library, Sinomed, WanFang Data, and Chinese Medical Journal Network. Results. This meta-analysis included a total of 40 moderate to high quality studies involving 3,002 patients. The overall rate of any hair regrowth was 69%, and the overall rate of complete hair regrowth was 23%. The rate of any hair regrowth in patients with alopecia totalis or alopecia universalis was 42%, and the rate of any hair regrowth in patients with other types of alopecia areata was 75%. Common side effects were mild contact dermatitis (36%), severe contact dermatitis (31%), regional lymphadenopathy (22%), hyperpigmentation (22%), and hypopigmentation (7%). The recurrence rate was 37%. Conclusion. Diphenylcyclopropenone topical immunotherapy is an effective treatment for various types of alopecia areata, and most of its common side effects are acceptable.

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二苯环丙烯局部免疫治疗斑秃的疗效、安全性和复发率:一项系统评价和荟萃分析

背景和目的。二苯环丙烯局部免疫疗法广泛应用于斑秃的治疗。然而，以往的研究表明其疗效存在显著差异。我们进行了这项系统回顾和荟萃分析，以调查二苯基环丙烯局部免疫治疗斑秃的疗效、安全性和复发率。方法。检索2002年1月1日至2022年7月2日期间有关二苯基环丙烯局部免疫治疗斑秃的相关文献:PubMed、Embase、Cochrane Library、sinmed、万方数据、中华医学期刊网。结果。本荟萃分析共纳入了40项中等至高质量的研究，涉及3,002例患者。任何头发再生的总比率为69%，完全头发再生的总比率为23%。全身性脱发或全身性脱发患者的毛发再生率为42%，其他类型斑秃患者的毛发再生率为75%。常见的副作用有轻度接触性皮炎(36%)、重度接触性皮炎(31%)、局部淋巴结病(22%)、色素沉着(22%)和色素沉着减少(7%)。复发率为37%。结论。二苯环丙烯局部免疫治疗是治疗各种类型斑秃的有效方法，其常见的副作用大多是可以接受的。

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来源期刊

Dermatologic Therapy 医学-皮肤病学

CiteScore

7.00

自引率

8.30%

发文量

711

审稿时长

3 months

期刊介绍： Dermatologic Therapy has been created to fill an important void in the dermatologic literature: the lack of a readily available source of up-to-date information on the treatment of specific cutaneous diseases and the practical application of specific treatment modalities. Each issue of the journal consists of a series of scholarly review articles written by leaders in dermatology in which they describe, in very specific terms, how they treat particular cutaneous diseases and how they use specific therapeutic agents. The information contained in each issue is so practical and detailed that the reader should be able to directly apply various treatment approaches to daily clinical situations. Because of the specific and practical nature of this publication, Dermatologic Therapy not only serves as a readily available resource for the day-to-day treatment of patients, but also as an evolving therapeutic textbook for the treatment of dermatologic diseases.