Formulation and in vitro Evaluation of Verapamil Hydrochloride Floating Tablets

Rima Kumari Prajapati, Sujatha P. Muchalambe, Hindustan Abdul Ahad, Saurabh Kumar Shukla, Pushpa Sahani
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Abstract

The present research work aims to formulate and evaluate novel sustained-discharge floating tablets of verapamilhydrochloride (VPH) which is used for the treatment of hypertension. We aim to use a direct compression technique to formulatethe floating tablets. The characterization of the formulation of VPH was carried out by employing FT-IR and DSC studies, whichshowed that there was no chemical interaction between the drug and polymers, such as HPMC K100M, chitosan, and sodiumalginate. The tablets are designed to have good in-vitro buoyancy, and they remain afloat in the dissolution medium. The bestformulation (F7) is chosen based on its maximum drug discharge (91.91±2.25%) and drug content (97.20±2.71%) over 12h. Thedischarge kinetics of the drug from the tablets are analyzed using various mathematical models, such as zero order, first order,Higuchi, and Korsmeyer's equations. These models help explain and predict drug discharge behavior over time. The studyconcludes that a proper balance between the sustained-release polymer and the gas-forming agent is essential for efficient in-vitrobuoyancy and sustained drug discharge. Formulation F7, which utilized sodium alginate, appears to be the most promising in termsof drug discharge and content.
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盐酸维拉帕米漂浮片的处方及体外评价
本研究旨在研制并评价新型治疗高血压的盐酸维拉帕米缓释漂浮片。我们的目的是采用直接压缩技术来配制浮片。通过FT-IR和DSC研究对VPH的配方进行了表征,结果表明该药物与聚合物(如HPMC K100M、壳聚糖和海藻酸钠)之间没有化学相互作用。这种药片被设计成具有良好的体外浮力,它们在溶解介质中保持漂浮。以其在12h内的最大出药量(91.91±2.25%)和含药量(97.20±2.71%)为标准,选择最佳处方(F7)。使用各种数学模型,如零阶、一阶、Higuchi和Korsmeyer方程,分析药物从药片中排出的动力学。这些模型有助于解释和预测药物随时间的排出行为。研究表明,缓释聚合物和成气剂之间的适当平衡对于有效的体外浮力和持续的药物释放至关重要。以海藻酸钠为原料的配方F7在药物排出量和含量方面是最有希望的。
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