Optimal Glycemic Control for Patients with Pancreatitis in the Intensive Care Unit: A Retrospective Study Based on a Large Intensive Care Unit Database

Abstract

Objectives: Stress hyperglycemia is a common complication of pancreatitis. This study aimed to determine optimal blood glucose control goals for patients with pancreatitis. Methods: We conducted a screening of adult patients diagnosed with pancreatitis who were admitted to the ICU using data from the Medical Information Marketplace for Intensive Care IV (MIMIC-IV) database. In total, 574 cases were enrolled in this study and were divided into four groups based on blood glucose levels. We investigated the effects of four groups on the prognosis of patients with pancreatitis. Results: The survival group exhibited lower Glu_mean and Glu_cv values, but there was no significant effect on mortality. Glu_cv and frequency of daily blood glucose monitoring were significantly correlated with length of hospital stay, but had no significant effect on length of ICU stay. Subgroup analysis showed that the mortality rate was the highest when the mean blood glucose was 7.8 - 10.0 mmol/L, and the lowest when Glu_mean was 6.1 - 7.8 mmol/L.