Relationship between MTHFR gene polymorphism and risk of thrombosis in postoperative patients with colorectal cancer

IF 2.4 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Experimental and therapeutic medicine Pub Date : 2023-11-03 DOI:10.3892/etm.2023.12287
Wei Zhang, Li Chen, Gaoyang Cao, Fei Wang, Engeng Chen
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Abstract

An association between the methylenetetrahydrofolate reductase (MTHFR) C667T genotype and the risk of colorectal cancer, as well as a link between MTHFR gene polymorphism and thrombosis, have been revealed. However, the connection between MTHFR gene polymorphism and the risk of thrombosis in patients with colorectal cancer has remained to be fully elucidated. The present study investigated the link between MTHFR gene polymorphism and basic clinical data, postoperative D‑dimer (DDi), postoperative thromboelastogram and postoperative thrombosis in 591 patients who underwent surgery for colorectal cancer. Postoperative DDi, thromboelastogram and postoperative thrombosis were not significantly different among patients with colorectal cancer and different MTHFR genotypes. While the results were ‘negative’, the present study may help physicians understand that it is not necessary to detect MTHFR polymorphism for therapeutic purposes. Regarding the danger of venous thrombosis, more focus should be placed on the standardized procedural enforcement system for deep vein thrombosis prevention for patients undergoing pelvic and abdominal surgery.
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结直肠癌术后患者MTHFR基因多态性与血栓形成风险的关系
亚甲基四氢叶酸还原酶(MTHFR) C667T基因型与结直肠癌风险之间的关联,以及MTHFR基因多态性与血栓形成之间的联系已经被揭示。然而,MTHFR基因多态性与结直肠癌患者血栓形成风险之间的关系仍有待充分阐明。本研究探讨591例大肠癌手术患者MTHFR基因多态性与基本临床资料、术后D -二聚体(DDi)、术后血栓弹性图及术后血栓形成的关系。术后DDi、血栓弹性图和术后血栓形成在结直肠癌患者和不同MTHFR基因型之间无显著差异。虽然结果是“阴性”,但目前的研究可能会帮助医生理解,为了治疗目的,没有必要检测MTHFR多态性。对于静脉血栓形成的危险性,盆腔及腹部手术患者预防深静脉血栓形成的规范化程序执行体系更应得到重视。
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Experimental and therapeutic medicine
Experimental and therapeutic medicine MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
1.50
自引率
0.00%
发文量
570
审稿时长
1 months
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