{"title":"To Synthesis and Characterization of Novel 1,3,4-Oxadiazinoindole Derivatives for the Purpose of Antidepressant Activity","authors":"Mahadev Agarwal, Neelam Singla, S.K Singh","doi":"10.25258/ijpqa.14.3.33","DOIUrl":null,"url":null,"abstract":"The present paper is based on the combination of MAOI hydrazide moiety and tricyclic antidepressant moiety. This combination investigates new compounds as 1,3,4-oxadiazinoindole derivatives to find potent and safer antidepressants. Synthesis of 1,3,4-oxadiazinoindole derivatives are started from various animoacids. The sequence of synthesis reactions such as benzoylation reaction, Halo-De-hydroxylation (Nucleophilic substitution reaction), Schotten-Baumann reaction, Nucleophilic addition and finally cyclization reaction (Cyclo-De-Hydroxylation) are involved. Synthesized compounds are characterized via melting point, TLC, FT infrared spectroscopy, 1H-NMR, and mass spectroscopy techniques. All compound’s structures are confirmed.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Pharmaceutical Quality Assurance","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.25258/ijpqa.14.3.33","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 0
Abstract
The present paper is based on the combination of MAOI hydrazide moiety and tricyclic antidepressant moiety. This combination investigates new compounds as 1,3,4-oxadiazinoindole derivatives to find potent and safer antidepressants. Synthesis of 1,3,4-oxadiazinoindole derivatives are started from various animoacids. The sequence of synthesis reactions such as benzoylation reaction, Halo-De-hydroxylation (Nucleophilic substitution reaction), Schotten-Baumann reaction, Nucleophilic addition and finally cyclization reaction (Cyclo-De-Hydroxylation) are involved. Synthesized compounds are characterized via melting point, TLC, FT infrared spectroscopy, 1H-NMR, and mass spectroscopy techniques. All compound’s structures are confirmed.
本论文是基于MAOI肼段和三环抗抑郁药段的组合。该组合研究了1,3,4-恶二嗪吲哚衍生物的新化合物，以发现有效且更安全的抗抑郁药。以各种氨基酸为原料合成1,3,4-恶二嗪吲哚衍生物。合成反应的顺序为苯甲酰化反应、halo - de -羟基化反应(亲核取代反应)、Schotten-Baumann反应、亲核加成反应，最后是环化反应(环- de -羟基化反应)。合成的化合物通过熔点、TLC、FT红外光谱、1H-NMR和质谱技术进行表征。所有化合物的结构都得到了确认。
期刊介绍：
INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE is a quarterly international journal publishing the finest peer-reviewed research in the field of Pharmaceutical Quality Assurance and Pharmaceutical Analysis on the basis of its originality, importance, disciplinary interest, timeliness, accessibility, elegance, and surprising conclusions. IJPQA also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.
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