Nutritional Composition, Capsaicin Content and Enzyme Inhibitory Activities from “Bang Chang” Thai Cultivar Chili Pepper (Capsicum annuum Var. acuminatum) after Drying Process

Q3 Pharmacology, Toxicology and Pharmaceutics International Journal of Pharmaceutical Quality Assurance Pub Date : 2023-09-25 DOI:10.25258/ijpqa.14.3.41
Kanyapat Petcharaporn, Kanittada Thongkao, Pimporn Thongmuang, Yuttana Sudjaroen
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Abstract

Chili pepper cultivars come in a broad variety of tastes, colors, sizes, and spiciness levels due to various growth conditions. The significance of different chili peppers and other spices in Thai cuisine may be seen in dishes. This study evaluated the nutritional composition and capsaicin content from “Bang Chang” Thai cultivar chili pepper after drying, and the inhibition of lipase, tyrosinase and elastase enzymes from its oil and ethanol extracts. The nutritional composition of sun-dried chili pepper was high dietary fiber and beta-carotene, which were significantly high amount portion of Thai recommended dietary intake (RDI). According to calculations and definitions, “Bang Chang chili pepper” is a non-pungent Capsicum (0-700 SHU) since it contains a low amount of capsaicin. Total phenolic content was more abundant in ethanol extract (2.50 ± 0.13 mg GAE/g) than oil extract (1.05 ± 0.05 mg GAE/g). Compared to the positive control orlistat (IC50 = 3.26 ± 0.28 mg/mL), an anti-lipase drug, ethanol extract was 2.0 times more lipase inhibitory. In addition, ethanol extract was mildly anti-tyrosinase, while oil extract was non-activity. The anti-lipase activity of ethanol extract was due to phenolic content rather than capsaicin contained and this enzyme inhibition may act on active site. We found that ethanol extract of “Bang Chang” cultivar chili pepper yielded higher TPC content and more effective anti-lipase than oil extract. The finding provided benefits on applying this chili pepper on anti-lipase use and weight management.
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泰国品种“邦昌”辣椒(Capsicum annuum Var. acuminatum)干燥后营养成分、辣椒素含量及酶抑制活性研究
由于不同的生长条件,辣椒品种有各种各样的口味、颜色、大小和辣度。不同的辣椒和其他香料在泰国菜中的重要性可以从菜肴中看出。研究了泰国品种“邦昌”辣椒干燥后的营养成分和辣椒素含量,以及其油和乙醇提取物对脂肪酶、酪氨酸酶和弹性酶的抑制作用。晒干辣椒的营养成分是高膳食纤维和β -胡萝卜素,这是泰国推荐膳食摄入量(RDI)的高含量部分。根据计算和定义,“邦昌辣椒”是一种不辛辣的辣椒(0-700 SHU),因为它含有少量的辣椒素。乙醇提取物的总酚含量(2.50±0.13 mg GAE/g)高于油提取物(1.05±0.05 mg GAE/g)。与阳性对照抗脂肪酶药物奥利司他(IC50 = 3.26±0.28 mg/mL)相比,乙醇提取物对脂肪酶的抑制作用提高了2.0倍。此外,乙醇提取物对酪氨酸酶有轻微的抗活性,而油提取物对酪氨酸酶无活性。乙醇提取物的抗脂肪酶活性主要是由于酚类物质的含量而不是辣椒素的含量,这种酶抑制作用可能发生在活性部位。结果表明,“帮昌”辣椒乙醇提取物的TPC含量高于油提取物,且抗脂肪酶活性更强。这一发现为将这种辣椒应用于抗脂肪酶的使用和体重管理提供了好处。
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来源期刊
International Journal of Pharmaceutical Quality Assurance
International Journal of Pharmaceutical Quality Assurance Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
CiteScore
0.80
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0.00%
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0
期刊介绍: INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE is a quarterly international journal publishing the finest peer-reviewed research in the field of Pharmaceutical Quality Assurance and Pharmaceutical Analysis on the basis of its originality, importance, disciplinary interest, timeliness, accessibility, elegance, and surprising conclusions. IJPQA also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.
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