Current state and challenges of emerging biomarkers for immunotherapy in hepatocellular carcinoma (Review)

IF 2.4 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Experimental and therapeutic medicine Pub Date : 2023-11-03 DOI:10.3892/etm.2023.12285
Mo Cheng, Xiufeng Zheng, Jing Wei, Ming Liu
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Abstract

Hepatocellular carcinoma (HCC) is the most prevalent form of primary liver cancer. According to the American Cancer Society, among patients diagnosed with advanced liver cancer, HCC has the sixth‑highest incident rate, resulting in a poor prognosis. Surgery, radiofrequency ablation, transcatheter arterial chemoembolization, radiation, chemotherapy, targeted therapy and immunotherapy are the current treatment options available. Immunotherapy, which has emerged as an innovative treatment strategy over the past decade, is serving a vital role in the treatment of advanced liver cancer. Since only a small number of individuals can benefit from immunotherapy, biomarkers are required to help clinicians identify the target populations for this precision medicine. These biomarkers, such as PD‑1/PD‑L1, tumor mutational burden and circulating tumor DNA, can be used to investigate interactions between immune checkpoint inhibitors and tumors. The present review summarizes information on the currently available biomarkers used for immunotherapy and the challenges that are present.
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肝细胞癌免疫治疗生物标志物的现状与挑战(综述)
肝细胞癌(HCC)是原发性肝癌最常见的形式。根据美国癌症协会的数据,在晚期肝癌患者中,HCC的发病率排在第六位,导致预后不良。手术、射频消融、经导管动脉化疗栓塞、放疗、化疗、靶向治疗和免疫治疗是目前可用的治疗选择。免疫疗法在过去十年中作为一种创新的治疗策略出现,在晚期肝癌的治疗中发挥着至关重要的作用。由于只有少数人可以从免疫治疗中受益,因此需要生物标志物来帮助临床医生确定这种精准医学的目标人群。这些生物标志物,如PD‑1/PD‑L1、肿瘤突变负担和循环肿瘤DNA,可用于研究免疫检查点抑制剂与肿瘤之间的相互作用。本文综述了目前可用的用于免疫治疗的生物标志物的信息和存在的挑战。
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来源期刊
Experimental and therapeutic medicine
Experimental and therapeutic medicine MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
1.50
自引率
0.00%
发文量
570
审稿时长
1 months
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