An exploratory study of 3rd wave features of COVID-19 patients admitted in a level 3 medical institution of Uttar Pradesh, India

Devinder Kumar Vohra, Sanjev Dave, Shalini Sharma, Santosh Mittal, Arvind Trivedi, J. K. Manchanda, Nawab Singh
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Abstract

Background: COVID-19 3rd wave has shown not only less deaths but also limited symptomatic patients in India with few numbers of casualties as compared to first and second wave. The exact scientific reason behind this needs detailed study. There is an urgent need for a study aimed towards detection of low mortality and morbidity in 3rd wave of COVID-19 patients from a level 3 medical college hospital in western Uttar Pradesh district in India so as to find and develop new management strategies for COVID-19 patients in future next COVID-19 waves. Methods: This study was aimed to find morbidity and mortality factors of COVID-19 3rd wave among COVID-19 patients in a level 3 medical college hospital in western UP district Saharanpur in India from 1st January 2022 to 30th June 2022. Results: The demographic profile of patients admitted in our level 3 medical college hospital in western UP district in India; had no significant (p>0.05) association with morbidity and mortality in COVID-19 3rd wave, but vaccination doses as it increased from 1st to 2nd had significant association (p=0.05) with less mortality and morbidity in COVID-19 3rd wave those who received the vaccines. Conclusions: Possibly COVID vaccination doses had a positive boosting effect on immune system of COVID-19 patients, which may have caused Virus to be less damaging to Immune system leading to decreased morbidity and mortality and in COVID-19 patients in wave 3.
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印度北方邦某三级医疗机构新冠肺炎患者第三波特征的探索性研究
背景:与第一波和第二波相比,第三波COVID-19在印度不仅死亡人数减少,而且有症状的患者也有限,伤亡人数很少。这背后确切的科学原因需要详细研究。迫切需要开展一项针对印度北方邦西部地区三级医学院医院第三波COVID-19患者低死亡率和低发病率的研究,以便在未来的下一波COVID-19患者中寻找和制定新的管理策略。方法:研究2022年1月1日至2022年6月30日在印度北方邦西部萨哈兰普尔区某三级医学院附属医院收治的新冠肺炎第三波发病和死亡因素。结果:对印度北方邦西部三级医学院附属医院住院患者的人口学特征进行了分析;与第三波发病率和死亡率无显著相关性(p>0.05),但接种疫苗剂量随接种时间的增加与第三波死亡率和发病率的降低有显著相关性(p=0.05)。结论:疫苗接种剂量可能对COVID-19患者免疫系统有正向增强作用,这可能导致病毒对免疫系统的损害较小,从而降低了第三波COVID-19患者的发病率和死亡率。
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