Recent advances in the natural products-based lead discovery for new agrochemicals

Advanced Agrochem Pub Date : 2023-12-01 DOI:10.1016/j.aac.2023.09.004

Pei Zhang , Chun-Bao Duan , Bing Jin , Abdallah S. Ali , Xinya Han , Haifeng Zhang , Ming-Zhi Zhang , Wei-Hua Zhang , Yu-Cheng Gu

{"title":"Recent advances in the natural products-based lead discovery for new agrochemicals","authors":"Pei Zhang , Chun-Bao Duan , Bing Jin , Abdallah S. Ali , Xinya Han , Haifeng Zhang , Ming-Zhi Zhang , Wei-Hua Zhang , Yu-Cheng Gu","doi":"10.1016/j.aac.2023.09.004","DOIUrl":null,"url":null,"abstract":"<div><p>Crops will be harmed by fungi, pests and weeds during their growth. In the past half century, scientists have conducted in-depth research on natural products extracted from microorganisms, plants or animals, and used natural products and their derivatives as the lead for pesticides discovery. Natural product pesticides have the advantages of easy degradation in the environment, selective control and safety to non-target organisms. This review summarizes the studies on natural products pesticides in recent years, including natural products of chemical modification and biosynthesis, mainly fungicides, herbicides, insecticides and acaricides. We classify natural products according to their active fragments, and discuss their effects on the control of agricultural fungi, pests and weeds. Ultimately, we found that lead discovery based on natural products has great advantages in pesticide development.</p></div>","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"2 4","pages":"Pages 324-339"},"PeriodicalIF":0.0000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773237123000795/pdfft?md5=b9f25096f9f6beacd9d4659fe262f1b2&pid=1-s2.0-S2773237123000795-main.pdf","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Agrochem","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2773237123000795","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 2

Abstract

Crops will be harmed by fungi, pests and weeds during their growth. In the past half century, scientists have conducted in-depth research on natural products extracted from microorganisms, plants or animals, and used natural products and their derivatives as the lead for pesticides discovery. Natural product pesticides have the advantages of easy degradation in the environment, selective control and safety to non-target organisms. This review summarizes the studies on natural products pesticides in recent years, including natural products of chemical modification and biosynthesis, mainly fungicides, herbicides, insecticides and acaricides. We classify natural products according to their active fragments, and discuss their effects on the control of agricultural fungi, pests and weeds. Ultimately, we found that lead discovery based on natural products has great advantages in pesticide development.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

基于天然产品的新型农用化学品先导发现的最新进展

农作物在生长过程中会受到真菌、害虫和杂草的危害。近半个世纪以来，科学家们对从微生物、植物或动物中提取的天然产物进行了深入研究，并以天然产物及其衍生物作为农药研发的先导。天然产物农药具有在环境中易降解、选择性防治、对非靶标生物安全等优点。本综述总结了近年来对天然产物农药的研究，包括化学修饰和生物合成的天然产物，主要有杀菌剂、除草剂、杀虫剂和杀螨剂。我们根据活性片段对天然产物进行了分类，并讨论了它们对农业真菌、害虫和杂草的防治效果。最终，我们发现基于天然产物的先导发现在农药开发中具有巨大优势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Advanced Agrochem

CiteScore

3.50

自引率

0.00%

发文量