A biodegradable drug-controlled delivery system based on mesoporous manganese dioxide and poly(dopamine)

IF 1.7 4区化学 Bulletin of the Korean Chemical Society Pub Date : 2023-10-18 DOI:10.1002/bkcs.12788

Miaomiao Li, Wenrong Cai, Lihua Jiang, Junyao Li, Shan Li, Tongtong Tang, Yong Kong

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Abstract

Mesoporous manganese dioxide (mMnO₂) was first synthesized for the loading of methotrexate (MTX), and then dopamine was in situ polymerized on the surface of the MTX-loaded mMnO₂ (mMnO₂-MTX) in an alkaline solution to encapsulate the drug in the mesopores of mMnO₂. Both low pH and glutathione (GSH) can result in the degradation of mMnO₂ and poly(dopamine) (PDA), and thus the delivery of MTX from the mMnO₂-MTX-PDA can be triggered by low pH and GSH. Near-infrared (NIR) light-responsive delivery of MTX can be achieved owing to the outstanding photothermal conversion capability of PDA; on the other hand, the mMnO₂-MTX-PDA can be utilized for photothermal therapy under the irradiation of NIR light due to the elevated temperature. The results of cytotoxicity test demonstrate that the pH, GSH, and NIR light tri-responsive drug-controlled delivery system has excellent biocompatibility, while exhibits pronounced growth inhibition against murine breast tumor cell line 4T1.

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基于介孔二氧化锰和聚多巴胺的生物可降解药物控制输送系统

首先合成了用于负载甲氨蝶呤（MTX）的介孔二氧化锰（mMnO2），然后在碱性溶液中将多巴胺原位聚合在负载MTX的mMnO2（mMnO2-MTX）表面，从而将药物封装在mMnO2的介孔中。低pH值和谷胱甘肽（GSH）都会导致mMnO2和聚（多巴胺）（PDA）降解，因此低pH值和GSH会触发mMnO2-MTX-PDA释放MTX。由于 PDA 具有出色的光热转换能力，可实现 MTX 的近红外光响应给药；另一方面，由于温度升高，mMnO2-MTX-PDA 可在近红外光照射下用于光热治疗。细胞毒性测试结果表明，pH、GSH 和近红外光三反应药物控制递送系统具有良好的生物相容性，同时对小鼠乳腺肿瘤细胞系 4T1 具有明显的生长抑制作用。

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来源期刊

Bulletin of the Korean Chemical Society Chemistry-General Chemistry

自引率

23.50%

发文量

182

期刊介绍： The Bulletin of the Korean Chemical Society is an official research journal of the Korean Chemical Society. It was founded in 1980 and reaches out to the chemical community worldwide. It is strictly peer-reviewed and welcomes Accounts, Communications, Articles, and Notes written in English. The scope of the journal covers all major areas of chemistry: analytical chemistry, electrochemistry, industrial chemistry, inorganic chemistry, life-science chemistry, macromolecular chemistry, organic synthesis, non-synthetic organic chemistry, physical chemistry, and materials chemistry.