Bioactive peptides against angiotensin‐converting enzyme I: An in silico study

IF 1.5 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Peptide Science Pub Date : 2023-09-23 DOI:10.1002/pep2.24332
Antistio Alvíz‐Amador, Neyder Contreras‐Puentes, Johana Márquez‐Lázaro
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Abstract

Abstract Bioactive peptides are currently emerging as nonpharmacological alternatives for treating noncommunicable diseases, including hypertension. Pharmacological treatments for hypertension typically involve angiotensin I converting enzyme inhibitors such as Captopril and enalapril. This study aimed to evaluate the activity of bioactive peptides derived from food sources against this enzyme and show its possible mechanism of inhibitory action. A comprehensive search was conducted in peptide databases to identify peptides with antihypertensive properties. Subsequently, docking studies, simulations, and predictive tests assessing ADME parameters, intestinal stability, and allergenicity were performed using bioinformatics tools. The docking and simulation results demonstrated that PEP2 exhibited superior ACE1 inhibitory potential compared to other peptides, even though it had lower human intestinal absorption. In conclusion, this study suggests that these peptides hold promising potential as nutraceuticals for hypertension treatment.
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抗血管紧张素转换酶I的生物活性肽:一项计算机研究
生物活性肽目前正成为治疗包括高血压在内的非传染性疾病的非药物替代品。高血压的药物治疗通常包括血管紧张素I转换酶抑制剂,如卡托普利和依那普利。本研究旨在评价从食物中提取的生物活性肽对该酶的活性,并揭示其可能的抑制作用机制。在肽数据库中进行了全面的搜索,以确定具有抗高血压特性的肽。随后,利用生物信息学工具进行对接研究、模拟和预测测试,评估ADME参数、肠道稳定性和过敏原性。对接和模拟结果表明,尽管PEP2的人体肠道吸收率较低,但与其他肽相比,它具有更好的ACE1抑制潜力。总之,本研究表明,这些肽作为高血压治疗的营养品具有很大的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Peptide Science
Peptide Science Biochemistry, Genetics and Molecular Biology-Biophysics
CiteScore
5.20
自引率
4.20%
发文量
36
期刊介绍: The aim of Peptide Science is to publish significant original research papers and up-to-date reviews covering the entire field of peptide research. Peptide Science provides a forum for papers exploring all aspects of peptide synthesis, materials, structure and bioactivity, including the use of peptides in exploring protein functions and protein-protein interactions. By incorporating both experimental and theoretical studies across the whole spectrum of peptide science, the journal serves the interdisciplinary biochemical, biomaterials, biophysical and biomedical research communities. Peptide Science is the official journal of the American Peptide Society.
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