In silico identification of cadmium binding protein and its secreted metalloproteins in Stenotrophomonas maltophilia

Nandhana Ganapathy Salini, Rikhia Majumdar, Shahjahan Ahamad, Shobana Sugumar
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Abstract

background: Stenotrophomonas maltophilia is a pathogenic bacteria that causes serious infectious complications in humans, especially in immune-compromised patients. Stenotrophomonas maltophilia is a gram-negative bacterium that is multidrug-resistant. objective: The purpose of the study is to understand the diverse cellular and biological functions of cadmium-binding metalloproteins and to predict their role in pathogenicity, regulation, and growth. methodology: Different in silico approaches were used to check the Functional Annotation, Subcellular Localization, Gene Ontology, and Bacterial toxin prediction have been used to identify the cellular and biological function of Cd-binding metalloproteins in Stenotrophomonas maltophilia. results: Identified 116 Cd-binding proteins from the whole proteome sequence and functional domain, family, localization, and toxicity were also studied. conclusion: The outcomes revealed that this study could be used in understanding the 116 cadmium-binding proteins from the whole proteome sequence. This study shows the survival, growth, and pathogenicity of the bacteria.
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嗜麦芽窄养单胞菌中镉结合蛋白及其分泌金属蛋白的计算机鉴定
背景:嗜麦芽窄养单胞菌是一种致病菌,可引起人类严重的感染性并发症,特别是在免疫功能低下的患者中。嗜麦芽窄养单胞菌是一种多重耐药的革兰氏阴性细菌。目的:了解镉结合金属蛋白的多种细胞和生物学功能,并预测其在致病性、调控和生长中的作用。方法:采用不同的计算机方法检查功能注释,亚细胞定位,基因本体论和细菌毒素预测用于鉴定嗜麦芽寡养单胞菌cd结合金属蛋白的细胞和生物学功能。结果:鉴定了116个cd结合蛋白的全蛋白质组序列,并对其功能域、家族、定位和毒性进行了研究。结论:本研究结果可用于从整个蛋白质组序列中了解116个镉结合蛋白。这项研究显示了细菌的生存、生长和致病性。
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来源期刊
Current Chemical Biology
Current Chemical Biology Medicine-Biochemistry (medical)
CiteScore
1.40
自引率
0.00%
发文量
16
期刊介绍: Current Chemical Biology aims to publish full-length and mini reviews on exciting new developments at the chemistry-biology interface, covering topics relating to Chemical Synthesis, Science at Chemistry-Biology Interface and Chemical Mechanisms of Biological Systems. Current Chemical Biology covers the following areas: Chemical Synthesis (Syntheses of biologically important macromolecules including proteins, polypeptides, oligonucleotides, oligosaccharides etc.; Asymmetric synthesis; Combinatorial synthesis; Diversity-oriented synthesis; Template-directed synthesis; Biomimetic synthesis; Solid phase biomolecular synthesis; Synthesis of small biomolecules: amino acids, peptides, lipids, carbohydrates and nucleosides; and Natural product synthesis).
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