Serum uric acid levels predict high hs-CRP levels in non-diabetic adult

Abstract

Introduction High-sensitivity C-reactive protein (hsCRP) is a microinflammation biomarker that has been widely accepted as an assessment tool for cardiovascular risk. Excess of serum uric acid levels is also linked to metabolic disorders and cardiovascular disease risk factors. Aim The study aimed to investigate the association between serum uric acid and cardiovascular risk defined based on hsCRP levels in non-diabetic adults. Material and methods This cross-sectional study included 90 non-diabetic adult subjects which comprised 45 males and 45 females. The uric acid test was performed by enzymatic colorimetric method while hsCRP was performed by immunoturbidimetric assay. High cardiovascular risk was defined as hsCRP of more than 3 mg/L. Results and discussion Serum uric acid had significant correlation with hsCRP levels in male and female subjects (r = 0.376, P = 0.011 and r = 0.378, P = 0.011, respectively). In male subjects, the uric acid cut-off of 7.415 mg/dL had 62.5% sensitivity and 83.8% specificity in predicting high cardiovascular risk (AUC = 0.671), while in females, the cut-off of 4.215 mg/dL had 73.3% sensitivity and 63.3% specificity (AUC = 0.704) in predicting the high risk. Males with uric acid of more than 7.415 mg/dL had 8.61 times having high cardiovascular risk compared those below the cut-off (P = 0.014, 95%CI = 1.609–46.07). Females with uric acid of more than 4.215 mg/dL had 4.75 times having high cardiovascular risk compared those below the cut-off (P = 0.02, 95%CI = 1.214–18.584). Conclusions Uric acid and hsCRP levels have a significant association. Serum uric acid levels may predict high cardiovascular risk defined based on hsCRP in males and females.