Clinical features and prognostic analysis of the blastoid variant of mantle cell lymphoma: An analysis of 20 patients from two centers

Sai Huang , Shaomei Liu , Hongmei Jing , Ping Chen , Lili Dong , Xiaoyu Hao , Jian Bo , Lu Sun , Yu Zhao
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套细胞淋巴瘤blastoid变种的临床特征和预后分析:对两个中心20名患者的分析
对2012年至2020年在两家医院住院的20名患者进行了回顾性分析。这些患者根据淋巴结病理和免疫组织化学结果被诊断为胚样变套细胞淋巴瘤(BV- mcl),其中15例为经典BV, 5例为多形性BV- mcl。Ki-67指数≥80% 9例(45.0%),Ki-67指数在60% ~ 79%之间9例(45.0%),Ki-67指数在30% ~ 59%之间2例(10.0%)。中位随访时间为24.0个月(11.6 ~ 93.2个月)。客观有效率为80.0%,复发10例(50.0%)。中位总生存期(OS)为24.0个月,2年OS率为55.0%。在16例可评估无进展生存期(PFS)的患者中,中位PFS为20.6个月,2年PFS率为30.1%。BV-MCL是一种侵袭性的套细胞淋巴瘤亚型,其特点是进展迅速,Ki-67增殖指数升高,复发率高。这些患者表现出较短的生存时间和较差的整体预后。
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来源期刊
Cancer pathogenesis and therapy
Cancer pathogenesis and therapy Surgery, Radiology and Imaging, Cancer Research, Oncology
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54 days
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