A Comprehensive Review on Herbal Nanoparticulate System through Intranasal Route for Management of Congenital-Neuro Zika Therapy

Q2 Pharmacology, Toxicology and Pharmaceutics Current Bioactive Compounds Pub Date : 2023-11-01 DOI:10.2174/1573407219666230420114706

Deepika Joshi, Priya Sharma

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Abstract

Backgroud: An arbovirus called the Zika virus is spread by Aedes mosquitoes. The Zika virus (ZIKV) epidemic that has recently spread over the Western Hemisphere (the Americas and the ongoing outbreak in Brazil) is now recognised as one of the main causes of neurologic disease and other potential neurologic consequences. Methods: There are currently no antivirals available, and vaccines are only available for some. Currently, only symptomatic treatment is available. Various herbal plants, vegetables, fruits, flowers, and microbes have been documented to exhibit antiviral activities possessing good tolerability and minimal side effects. Polyphenols and other phyto-constituents have been extensively studied against arboviruses and have demonstrated promising results. Results: This review article focuses on a potential new herbal formulation with strong antiviral properties against the current zika virus and accompanying symptoms, with intranasal administration as the preferred method for treating neurological symptoms. Conclusion: Natural anti-viral therapy plays an important role in contributing to antiviral drug development and in reducing the global infection burden of arboviruses.

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经鼻经中药纳米颗粒系统治疗先天性神经寨卡的综合综述

背景:一种叫做寨卡病毒的虫媒病毒是由伊蚊传播的。最近在西半球(美洲和正在巴西暴发的寨卡病毒)蔓延的寨卡病毒流行现已被认为是神经系统疾病和其他潜在神经系统后果的主要原因之一。方法:目前没有抗病毒药物可用，只有一些疫苗可用。目前，只有对症治疗。各种草本植物、蔬菜、水果、花卉和微生物都显示出具有良好耐受性和最小副作用的抗病毒活性。多酚和其他植物成分已被广泛研究用于防治虫媒病毒，并显示出令人鼓舞的结果。结果:本文综述了一种潜在的新型草药配方，对当前寨卡病毒及其伴随症状具有强大的抗病毒特性，鼻内给药是治疗神经系统症状的首选方法。结论:天然抗病毒治疗在促进抗病毒药物开发和减轻虫媒病毒全球感染负担方面发挥着重要作用。

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来源期刊

Current Bioactive Compounds Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

1.90

自引率

0.00%

发文量

112

期刊介绍： The journal aims to provide comprehensive review articles on new bioactive compounds with proven activities in various biological screenings and pharmacological models with a special emphasis on stereoeselective synthesis. The aim is to provide a valuable information source of bioactive compounds synthesized or isolated, which can be used for further development of pharmaceuticals by industry and academia. The journal should prove to be essential reading for pharmacologists, natural product chemists and medicinal chemists who wish to be kept informed and up-to-date with the most important developments on new bioactive compounds of natural or synthetic origin, including their stereoeselective synthesis.