Synthesis, Characterization and Antimicrobial Evaluation of Amino acid Derivatives of 1,3,4-Oxadiazole

Abstract

Several novel 1,3,4-oxadiazole compounds were synthesized for this investigation. NMR and IR spectrum analysis as well as carbon, hydrogen, and nitrogen studies were used to characterize these novel synthesized compounds. Antibacterial and antifungal tests were conducted on all of the newly synthesized compounds. Staphylococcus aureus and Bacillus subtilis, both Gram +ve bacteria, and Escherichia coli and Pseudomonas aureginosa, both Gram -ve bacteria, were utilised in antibacterial studies. Aspergillus niger and Candida albicans were used to test the efficacy of antifungal treatments. Ciprofloxacin and fluconazole were utilized as reference medications in antibacterial and antifungal research, respectively. The inhibitory effects ranged from mild to strong across all of the substances. The results of the screenings showed that several of the compounds had stronger antibacterial and antifungal properties than the standard medicines.