Formulation and Optimization of Fast Dissolving Film Containing Rizatriptan Benzoate

Abstract

Fast-dissolving films are developed to overcome difficulty with swallowing which encountered not only in pediatric or geriatric populations but also in the case of handicapped, mentally retarded or bedridden patients. The present study was aimed to formulate fast dissolving film to enhance bioavailability and to avoid first pass effect. The key is to develop successful fast dissolving film by solvent casting method and select right compatible excipients using FTIR and DSC study. The present study describes formulation, optimization and evaluation of fast dissolving film of rizatriptan benzoate in which physical and mechanical parameter such as appearance, thickness, folding endurance, surface pH, disintegration time, in-vitro drug release was evaluated. The formulation was optimized by Box-Behnken design using Design Expert software. The effect of film-forming polymer composition and plasticizer concentration on disintegration time and in-vitro drug release behavior were investigated. The F8 batch was an optimized formulation with less disintegration time of 09 seconds and high in-vitro drug release of 99.58%