Effect of statin on mortality in diabetic patients with COVID-19: A systematic review and meta-analysis

IF 0.2 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Research in Cardiovascular Medicine Pub Date : 2023-01-01 DOI:10.4103/rcm.rcm_39_22
Kamran Roudini, Azin Alizadehasl, DavoodKhoda Amorzideh, Nashmil Ghadimi, Hossein Hosseinifard, Sara Kaveh, NiloufarAkbari Parsa
{"title":"Effect of statin on mortality in diabetic patients with COVID-19: A systematic review and meta-analysis","authors":"Kamran Roudini, Azin Alizadehasl, DavoodKhoda Amorzideh, Nashmil Ghadimi, Hossein Hosseinifard, Sara Kaveh, NiloufarAkbari Parsa","doi":"10.4103/rcm.rcm_39_22","DOIUrl":null,"url":null,"abstract":"Context: It seems that the threat of death increases among diabetic patients with coronavirus infection disease-2019 (COVID-19). Statins have anti-inflammatory and anti-thrombogenic properties along with lowering blood cholesterol. Therefore, statins could be considered as an important factor in reducing the mortality rates in diabetic patients with COVID-19. This systematic review and meta-analysis study was performed to investigate the effect of statin on mortality in diabetic patients with COVID-19. Evidence Acquisition: This study was done based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Electronic databases such as PubMed, Embase, Scopus, Web of Science, and Cochrane Library were searched from December 2019 until the end of September 2022. Meta-analysis was used by the comprehensive meta-analysis software to combine the results. A funnel plot and Egger’s regression test were used to investigate the publication bias. Results: Six studies were included in the meta-analysis. Nine thousand five hundred and thirty-three diabetic patients with COVID-19 were studied. The heterogeneity between studies was significant. According to the meta-analysis, using the random-effects model, we found that the rate of mortality due to COVID-19 in diabetic patients who used statins was 9% lower than other patients. Publication bias between studies included in the meta-analysis was not significant. Conclusions: In this study, there was no significant difference between the mortality rates of diabetic people with COVID-19 who used statins and individuals who did not consume statins – this difference was just 9%. Therefore, it could be said that more clinical trials are needed to ensure the clinical efficacy of statins among diabetic patients with COVID-19.","PeriodicalId":21031,"journal":{"name":"Research in Cardiovascular Medicine","volume":null,"pages":null},"PeriodicalIF":0.2000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Research in Cardiovascular Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/rcm.rcm_39_22","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0

Abstract

Context: It seems that the threat of death increases among diabetic patients with coronavirus infection disease-2019 (COVID-19). Statins have anti-inflammatory and anti-thrombogenic properties along with lowering blood cholesterol. Therefore, statins could be considered as an important factor in reducing the mortality rates in diabetic patients with COVID-19. This systematic review and meta-analysis study was performed to investigate the effect of statin on mortality in diabetic patients with COVID-19. Evidence Acquisition: This study was done based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Electronic databases such as PubMed, Embase, Scopus, Web of Science, and Cochrane Library were searched from December 2019 until the end of September 2022. Meta-analysis was used by the comprehensive meta-analysis software to combine the results. A funnel plot and Egger’s regression test were used to investigate the publication bias. Results: Six studies were included in the meta-analysis. Nine thousand five hundred and thirty-three diabetic patients with COVID-19 were studied. The heterogeneity between studies was significant. According to the meta-analysis, using the random-effects model, we found that the rate of mortality due to COVID-19 in diabetic patients who used statins was 9% lower than other patients. Publication bias between studies included in the meta-analysis was not significant. Conclusions: In this study, there was no significant difference between the mortality rates of diabetic people with COVID-19 who used statins and individuals who did not consume statins – this difference was just 9%. Therefore, it could be said that more clinical trials are needed to ensure the clinical efficacy of statins among diabetic patients with COVID-19.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
他汀类药物对糖尿病合并COVID-19患者死亡率的影响:系统综述和荟萃分析
背景:患有冠状病毒感染-2019 (COVID-19)的糖尿病患者的死亡威胁似乎有所增加。他汀类药物具有抗炎和抗血栓形成的特性以及降低血液中的胆固醇。因此,他汀类药物可被认为是降低糖尿病合并COVID-19患者死亡率的重要因素。本系统综述和荟萃分析研究旨在探讨他汀类药物对糖尿病合并COVID-19患者死亡率的影响。证据获取:本研究是根据系统评价和荟萃分析指南的首选报告项目完成的。从2019年12月到2022年9月底,检索了PubMed、Embase、Scopus、Web of Science和Cochrane Library等电子数据库。采用综合meta分析软件对结果进行综合分析。采用漏斗图和Egger回归检验检验发表偏倚。结果:6项研究被纳入meta分析。对9533例糖尿病合并COVID-19患者进行了研究。研究间的异质性显著。根据meta分析,使用随机效应模型,我们发现使用他汀类药物的糖尿病患者因COVID-19的死亡率比其他患者低9%。纳入meta分析的研究之间的发表偏倚不显著。结论:在这项研究中,使用他汀类药物的COVID-19糖尿病患者和未使用他汀类药物的患者的死亡率没有显著差异,差异仅为9%。因此,需要更多的临床试验来确保他汀类药物在糖尿病合并COVID-19患者中的临床疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Research in Cardiovascular Medicine
Research in Cardiovascular Medicine CARDIAC & CARDIOVASCULAR SYSTEMS-
自引率
0.00%
发文量
13
审稿时长
17 weeks
期刊最新文献
An unusual presentation of a rare case of rhabdomyosarcoma of the left atrium as severe rheumatic mitral stenosis with atrial fibrillation, fast ventricular rate, and left atrial failure Prognostic value of cardiac and noncardiac biomarkers in infective endocarditis: A prospective cross-sectional study Transcatheter closure of the aortopulmonary window with a multifunctional occluder device Predictions of adherence to treatment in patients referred to the heart failure clinic of Shahid Rajaee Hospital in Tehran The association between statin dosage and malignant ventricular arrhythmias in patients with primary prevention implantable cardioverter-defibrillators for ischemic cardiomyopathy
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1