Synthesizing of Alginate Coated-Silver Nanoparticles Core-Shell for Detecting of S-naproxen Enantiomer in Pharmaceutical Formulation

Abstract

Core-shell nanoparticles were used in a unique direct UV-Vis spectrophotometric technique to detect the S-naproxen enantiomer. Silver nanoparticles (Ag NPs) covered with sodium alginate (Alg) shell, a naturally occurring biopolymer, made the core of the nanostructure. To name a few, TEM, FESEM, UV-Visible, DLS, ZP, AFM, XRD, EDX and FT-IR are among the analytical methods used to analyze the creation of the core-shell structure. Based on obtained results, spherical Ag@ Alg NPs with an average size of 27.4 nm (DTEM), hydrolytic size of 46 nm (DDLS) and surface charge of -60.9 mV were successfully synthesized. The effect of various reaction time and pH values on determining the s-naproxen enantiomer by Ag@ Alg NPs was investigated. Determining the maximum S-naproxen enantiomer was at a reaction time of 8 min and pH 8. According to the international council for the harmonization of technical requirements for pharmaceuticals for human use (ICH) guidelines, the detection limit and quantitative limit of S-naproxen enantiomer were determined to be 1.87x10-4 mol/L and 5.64 x 10-4 mol /L. This clearly indicates that the alginate-coated silver na-noparticle