Studies on the formulation and functionality of an innovative line of topical products for atopic skin

IF 0.4 4区 医学 Q4 PHARMACOLOGY & PHARMACY Acta poloniae pharmaceutica Pub Date : 2023-10-11 DOI:10.32383/appdr/170202
Joanna Matysiak, Natalia Rzetecka, Weronika Klimczak, Bożena Michniak-Kohn, Jan Matysiak, Daria Szymanowska
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Abstract

Dermocosmetics are products intended for sensitive and problematic skin. They are a good solution for additional care of skin affected by conditions such as atopic dermatitis, acne, psoriasis, or for couperose skin. The compounds of particular importance in the care of atopic skin include ceramides, ectoine, hyaluronic acid, vitamins A and E, as well as natural vegetable oils. The aim of this work was to develop a qualitative and quantitative approach and to investigate the characteristics of formulations such as a face cream, a topical cream, a body lotion, and a cleansing foam, dedicated to patients with atopic dermatitis. The newly developed cosmetic formulations showed good physical and chemical characteristics, typical of this type of product. They were also structurally and microbiologically stable during storage at various temperatures. Dermatological tests did not reveal any irritating or allergenic properties. The best data were obtained for the face cream, namely improvement of skin hydration by 21.88%, reduction of transepidermal water loss by 15.86%, alleviation of erythema by 15.77%, and of skin sensitivity by 17.20%. This work resulted in the preparation of innovative dermocosmetics to be used for atopic skin. The cosmetics have a unique composition and delicate formula, show high biofunctionality, and meet all the requirements for cosmetic products intended for marketing.
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特应性皮肤局部产品创新系列的配方和功能研究
皮肤化妆品是为敏感和有问题的皮肤设计的产品。对于受特应性皮炎、痤疮、牛皮癣等皮肤病影响的皮肤,它们是一种很好的额外护理解决方案。在特应性皮肤护理中特别重要的化合物包括神经酰胺、外托因、透明质酸、维生素A和E,以及天然植物油。这项工作的目的是开发一种定性和定量的方法,并调查配方的特点,如面霜、局部面霜、身体乳和清洁泡沫,专门用于特应性皮炎患者。新开发的化妆品配方具有良好的物理和化学特性,是该类产品的典型。在不同的温度下,它们在结构和微生物方面也很稳定。皮肤测试没有发现任何刺激或过敏特性。结果显示,该面霜效果最佳,改善皮肤水合作用21.88%,减少经皮失水15.86%,减轻红斑15.77%,改善皮肤敏感性17.20%。这项工作导致了用于特应性皮肤的创新皮肤化妆品的制备。该化妆品具有独特的成分和精致的配方,具有很高的生物功能性,满足市场对化妆品的所有要求。
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来源期刊
CiteScore
0.80
自引率
0.00%
发文量
74
审稿时长
6-12 weeks
期刊介绍: The international journal of the Polish Pharmaceutical Society is published in 6 issues a year. The journal offers Open Access publication of original research papers, short communications and reviews written in English, in all areas of pharmaceutical sciences. The following areas of pharmaceutical sciences are covered: Analysis, Biopharmacy, Drug Biochemistry, Drug Synthesis, Natural Drugs, Pharmaceutical Technology, Pharmacology and General. A bimonthly appearing in English since 1994, which continues “Acta Poloniae Pharmaceutica”, whose first issue appeared in December 1937. The war halted the activity of the journal’s creators. Issuance of “Acta Poloniae Pharmaceutica” was resumed in 1947. From 1947 the journal appeared irregularly, initially as a quarterly, then a bimonthly. In the years 1963 – 1973 alongside the Polish version appeared the English edition of the journal. Starting from 1974 only works in English are published in the journal. Since 1995 the journal has been appearing very regularly in two-month intervals (six books a year). The journal publishes original works from all fields of pharmacy, summaries of postdoctoral dissertations and laboratory notes.
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