Bazı etanolik bitki ekstrelerinin histon deasetilaz inhibitör ve antioksidan aktiviteleri: Kanser için yeni bir terapötik yaklaşım

IF 0.3 Q3 MEDICINE, GENERAL & INTERNAL Cukurova Medical Journal Pub Date : 2023-09-30 DOI:10.17826/cumj.1316664

Eda DAĞSUYU, Refiye YANARDAĞ

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Abstract

Purpose: The aim of this study was to evaluate histone deacetylase inhibitory and antioxidant activities of some ethanolic plant extracts. Materials and Methods: In this study, the inhibitory effects of ethyl alcohol extracts prepared from various plants and some chemical compounds on histone deacetylase activity were investigated. In addition, the antioxidant activity of plant-derived active substances, which have had an important value in alternative medicine in recent years, has been determined to replace chemicals. Results: All the plant extracts and chemical substances used in the study showed histone deacetylase inhibitory effect (with IC50 range of 0.000078-319.0 µg/mL) and antioxidant activity. The results indicated that the percentage of histone deacetylase inhibition and antioxidant activities increased with increasing concentrations of the plant extracts and chemical compounds. Conclusion: These plant extracts which are potential sources of histone deacetylase inhibitors may be appropriately used as an alternative support to drug treatment rather than the use of toxic chemicals.

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一些乙醇植物提取物的组蛋白去乙酰化酶抑制和抗氧化活性：治疗癌症的新方法

目的:研究几种植物乙醇提取物对组蛋白去乙酰酶的抑制作用和抗氧化活性。& # x0D;材料与方法:研究了不同植物乙醇提取物及化合物对组蛋白去乙酰化酶活性的抑制作用。此外，近年来在替代医学中具有重要价值的植物源性活性物质的抗氧化活性已被确定为替代化学药品。结果:所有植物提取物和化学物质均具有抑制组蛋白去乙酰化酶的作用(IC50范围为0.000078 ~ 319.0µg/mL)和抗氧化活性。结果表明，组蛋白去乙酰化酶抑制率和抗氧化活性随植物提取物和化合物浓度的增加而增加。& # x0D;结论:这些植物提取物是组蛋白去乙酰化酶抑制剂的潜在来源，可以适当地作为药物治疗的替代支持，而不是使用有毒化学物质。

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