{"title":"ADAR1 Inhibits Macrophage Apoptosis and Alleviates Sepsis-induced Liver Injury Through miR-122/BCL2A1 Signaling","authors":"Shanshou Liu, Jiangang Xie, Chujun Duan, Xiaojun Zhao, Zhusheng Feng, Zheng Dai, Xu Luo, Yu Li, Minghe Yang, Ran Zhuang, Junjie Li, Wen Yin","doi":"10.14218/jcth.2023.00171","DOIUrl":null,"url":null,"abstract":"Background and AimsAs sepsis progresses, immune cell apoptosis plays regulatory roles in the pathogenesis of immunosuppression and organ failure. We previously reported that adenosine deaminases acting on RNA-1 (ADAR1) reduced intestinal and splenic inflammatory damage during sepsis. However, the roles and mechanism of ADAR1 in sepsis-induced liver injury remain unclear.","PeriodicalId":15484,"journal":{"name":"Journal of Clinical and Translational Hepatology","volume":"49 8","pages":"0"},"PeriodicalIF":3.1000,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical and Translational Hepatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14218/jcth.2023.00171","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
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Abstract
Background and AimsAs sepsis progresses, immune cell apoptosis plays regulatory roles in the pathogenesis of immunosuppression and organ failure. We previously reported that adenosine deaminases acting on RNA-1 (ADAR1) reduced intestinal and splenic inflammatory damage during sepsis. However, the roles and mechanism of ADAR1 in sepsis-induced liver injury remain unclear.
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