Evaluation of osteogenesis processes against the background of experimental osteoporosis therapy

Abstract

Background. Osteoporosis is a problem all over the world with important clinical and economic consequences. A significant contribution to solving the problem of the spread of osteoporosis can be the creation of drugs based on unique biologically active compounds. The aim was to evaluate the processes of osteogenesis, according to the formation of an organic matrix of bone tissue, as well as to evaluate markers of bone remodeling in blood serum at the stages of anti-osteoporosis therapy. Materials and methods. The study was performed on an experimental model of osteoporosis using biochemical methods for analyzing markers of osteoporosis in blood serum, as well as atomic absorption spectroscopy and X-ray densitometry. Results. According to the results of the study, the specific anti-osteoporotic activity of the new drug based on succinic acid salts was proved - a significant increase in the organic component the total collagen in bone tissue and the mineral component - the main elements in bone tissue in both young and old senile animals. Evaluation of the dynamics of the content of markers of bone remodeling showed the high effectiveness of the new drug in monotherapy, and in combination with vitamin D3 in the activation of osteogenesis processes in experimental osteoporosis. Conclusion. The effectiveness of the proposed anti-osteoporotic agent is shown, which is more pronounced in senile rats and is due to a proportional increase in the organic and mineral components of bone tissue.