{"title":"Effects of ischemia-reperfusion injury on microvascular permeability in skeletal muscle.","authors":"W N Durán, P K Dillon","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Microvascular permeability changes (using FITC-dextran 150 clearance as an index) produced by ischemia-reperfusion (I-R) were investigated in the rat cremaster muscle. I-R produced significant sustained increases in microvascular permeability to macromolecules. Pretreatment with dexamethasone and verapamil reduced this I-R effect. Leukopenia also afforded protection to the microcirculation. It was concluded that changes occurring during ischemia are major causative components of the ischemia-reperfusion damage.</p>","PeriodicalId":18718,"journal":{"name":"Microcirculation, endothelium, and lymphatics","volume":"5 3-5","pages":"223-39"},"PeriodicalIF":0.0000,"publicationDate":"1989-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microcirculation, endothelium, and lymphatics","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Microvascular permeability changes (using FITC-dextran 150 clearance as an index) produced by ischemia-reperfusion (I-R) were investigated in the rat cremaster muscle. I-R produced significant sustained increases in microvascular permeability to macromolecules. Pretreatment with dexamethasone and verapamil reduced this I-R effect. Leukopenia also afforded protection to the microcirculation. It was concluded that changes occurring during ischemia are major causative components of the ischemia-reperfusion damage.
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