Compensatory adrenal hypertrophy following unilateral adrenalectomy of fetuses of rats given alcohol throughout gestation.

Fetal therapy Pub Date : 1989-01-01 DOI:10.1159/000263447
K Arishima, M Lee, M Yamamoto, Y Eguchi
{"title":"Compensatory adrenal hypertrophy following unilateral adrenalectomy of fetuses of rats given alcohol throughout gestation.","authors":"K Arishima,&nbsp;M Lee,&nbsp;M Yamamoto,&nbsp;Y Eguchi","doi":"10.1159/000263447","DOIUrl":null,"url":null,"abstract":"<p><p>The effect of maternal alcohol consumption on fetal compensatory adrenal hypertrophy following unilateral adrenalectomy was studied in rats. Females were given 20% alcohol in tap water for 4 weeks prior to mating and 30% alcohol in tap water throughout gestation (alcohol), or were pair-fed to the alcohol group (pair-fed) or were fed ad libitum (control). On day 20, fetuses were unilaterally left-adrenalectomized or sham operated. Mothers were sacrificed on day 22 of gestation and right adrenals of adrenalectomized, sham-operated, and unoperated fetuses were removed and weighed. Some adrenals were fixed, sectioned, and stained for histological examination. Adrenalectomized fetuses of all three dietary treatment groups demonstrated compensatory hypertrophy. Adrenals of alcohol-exposed fetuses weighed less than those of pair-fed or control fetuses, and the ratio of adrenal weight/body weight was greater, regardless of surgical procedure. Histological sections of right adrenals of left-adrenalectomized fetuses showed larger cells and widened sinusoids, compared to unoperated fetuses in the corresponding dietary treatment groups. These results are consistent with a retardation in adrenal growth and development as a result of alcohol exposure, but show that alcohol consumption throughout gestation does not affect the ability of the adrenals to undergo compensatory hypertrophy following unilateral adrenalectomy.</p>","PeriodicalId":77713,"journal":{"name":"Fetal therapy","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000263447","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fetal therapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000263447","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1

Abstract

The effect of maternal alcohol consumption on fetal compensatory adrenal hypertrophy following unilateral adrenalectomy was studied in rats. Females were given 20% alcohol in tap water for 4 weeks prior to mating and 30% alcohol in tap water throughout gestation (alcohol), or were pair-fed to the alcohol group (pair-fed) or were fed ad libitum (control). On day 20, fetuses were unilaterally left-adrenalectomized or sham operated. Mothers were sacrificed on day 22 of gestation and right adrenals of adrenalectomized, sham-operated, and unoperated fetuses were removed and weighed. Some adrenals were fixed, sectioned, and stained for histological examination. Adrenalectomized fetuses of all three dietary treatment groups demonstrated compensatory hypertrophy. Adrenals of alcohol-exposed fetuses weighed less than those of pair-fed or control fetuses, and the ratio of adrenal weight/body weight was greater, regardless of surgical procedure. Histological sections of right adrenals of left-adrenalectomized fetuses showed larger cells and widened sinusoids, compared to unoperated fetuses in the corresponding dietary treatment groups. These results are consistent with a retardation in adrenal growth and development as a result of alcohol exposure, but show that alcohol consumption throughout gestation does not affect the ability of the adrenals to undergo compensatory hypertrophy following unilateral adrenalectomy.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
妊娠期间给予酒精的大鼠胎儿单侧肾上腺切除术后代偿性肾上腺肥大。
在大鼠中研究了母亲饮酒对单侧肾上腺切除术后胎儿代偿性肾上腺肥大的影响。雌性在交配前4周给予含20%酒精的自来水,在整个妊娠期间给予含30%酒精的自来水(酒精),或成对喂食给酒精组(成对喂食)或随意喂食(对照组)。第20天,单侧左肾上腺切除或假手术。母鼠于妊娠第22天处死,切除右肾上腺,假手术,未手术的胎儿取下并称重。部分肾上腺固定、切片、染色进行组织学检查。所有三个饮食治疗组肾上腺切除的胎儿均表现出代偿性肥厚。与手术方式无关,酒精暴露胎儿的肾上腺重量低于配对喂养或对照组胎儿,肾上腺重量/体重之比更大。左肾上腺切除胎儿的右肾上腺的组织学切片显示,与相应饮食治疗组未手术的胎儿相比,右肾上腺细胞更大,窦变宽。这些结果与酒精暴露导致的肾上腺生长发育迟缓一致,但表明整个妊娠期饮酒并不影响单侧肾上腺切除术后肾上腺代偿性肥大的能力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Fetal Infections: Immune Response to Infections during Fetal Life Twin-to-Twin Transfusion Syndrome: Placental and Fetal Pathogenesis Human Genetics and Fetal Disease: Assessment of the Fetal Genome A Fetal Origin of Adult Disease Fetal Cerebral Consequences of Structural Heart Disease: Can These Be Ameliorated?
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1