Clinical and pharmacological effectiveness of Fit-O-Metrin drug in the scheme of treatment of bovine postpartum metritis

Abstract

The article presents data on the approval of the new Fit-O-Metrin drug for accelerating the recovery of cows from postpartum metritis. The experiment was focused on monitoring the excretion of exudate; restoration and strengthening of the contractile function and regenerative processes in the uterus after the use of the drug. Favorable conditions for uterine disease are often created during calving. However, the reproductive function of animals is mostly determined by the ability to restore the physiological state of the uterus in the postpartum period. Thus, in the experimental farm AgroTsvit 2012 (Zhytomyr region), clinical and laboratory examination of cows in the postpartum period determined that the prevalence of metritis covers up to 42% of the herd. The largest percentage of sick cows had purulent form (53.1 %), catarrhal-purulent metritis was registered in 30.4 %, catarrhal – in 16.5 %. Through our own research, we determined the effectiveness of the experimental drug Fit-O-Metrin, made on the basis of plant materials (extract of thyme, motherwort, and common barberry) for intrauterine administration as part of the treatment regimen for bovine metritis. In the clinical test, 13 sick cows were involved, to which Fit-O-Metrin was applied according to three different schemes. Another 5 animals with metritis were included in the control group, which were treated according to the standard protocol for the farm. However, regardless of the chosen scheme, the complete cessation of the release of inflammatory exudate from the vagina of the entire cow's herd was recorded already on the 6–7 day (in the control group – on the 9 day). Normalization of tone and anatomical position of the uterus, complete closure of the cervical canal was noted on the 8th day (in the control group – on the 12 day). The most optimal scheme of using the herbal preparation against postpartum purulent metritis is 2 days injections, 2 days break, 2 days injections, 2 days break, final injection. A single dose of the FitO-Metrin drug is 30 ml. Key words: postpartum metritis, Fit-O-Methrin, cattle, treatment scheme, effectiveness, exudate, sexual cycle.