Influence of pregnancy and lactation on vitamin D serum levels and antioxidant status in randomized women in Zaria

Ohunene Avidime, S Avidime, A.J. Randawa, M.U. Kawu, A. Mohammed, O.T. Oweh
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Abstract

Pregnancy and lactation are normal physiological conditions that tend to influence numerous biological processes. The aim of this study was to identify the impact of pregnancy and lactation on serum vitamin D level and antioxidant status in some women in Zaria, Nigeria. A cross‑sectional descriptive study conducted at Ahmadu Bello University Teaching Hospital, Zaria for a period of three (3) months. Blood samples were collected, serum catalase, superoxide dismutase, lipid peroxidation and vitamin D, were determined using standard methods. Data were presented as mean ± SD, analysis was performed using one-way ANOVA and Pearson’s correlation analysis. Values were considered significant at p ≤ 0.05. There was a significant difference (p < 0.01) serum malondialdehyde level, superoxide dismutase activity and glutathione peroxidase activity during the various trimesters of pregnancy and lactating group. However, the levels of these markers were highest in the lactating group. Furthermore, serum level of vitamin D and catalase activity was highest in the 2nd trimester and lowest in the control and lactating group respectively. Pregnancy and lactation altered serum level of Vitamin D, CAT, SOD, MDA and GPx suggesting a variation in oxidative stress at different trimester of pregnancy and lactation. Key words: Pregnancy, lactation, oxidative stress, vitamin D
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妊娠和哺乳期对扎里亚随机妇女血清维生素D水平和抗氧化状态的影响
怀孕和哺乳是正常的生理状况,往往会影响许多生物过程。本研究的目的是确定怀孕和哺乳对尼日利亚扎里亚一些妇女血清维生素D水平和抗氧化状态的影响。在Zaria的Ahmadu Bello大学教学医院进行了为期三(3)个月的横断面描述性研究。采集血样,采用标准方法测定血清过氧化氢酶、超氧化物歧化酶、脂质过氧化和维生素D含量。数据以均数±标准差表示,分析采用单因素方差分析和Pearson相关分析。p≤0.05认为值显著。有显著性差异(p <0.01)妊娠和哺乳期各组血清丙二醛水平、超氧化物歧化酶活性和谷胱甘肽过氧化物酶活性。然而,这些标志物的水平在哺乳期组最高。血清维生素D水平和过氧化氢酶活性在妊娠中期最高,对照组和泌乳组最低。妊娠和哺乳期小鼠血清维生素D、CAT、SOD、MDA和GPx水平均发生变化,提示妊娠和哺乳期不同时期氧化应激水平存在差异。关键词:妊娠,哺乳,氧化应激,维生素D
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来源期刊
Nigerian Journal of Physiological Sciences
Nigerian Journal of Physiological Sciences Medicine-Physiology (medical)
CiteScore
0.80
自引率
0.00%
发文量
23
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