Calcium channelopathies in neurodegenerative disorder: an untold story of RyR and SERCA.

IF 4.6 2区医学 Q1 PHARMACOLOGY & PHARMACY Expert Opinion on Therapeutic Targets Pub Date : 2023-07-01 Epub Date: 2023-12-07 DOI:10.1080/14728222.2023.2277863

Maanvi Dhureja, Richmond Arthur, Divya Soni, Shubham Upadhayay, Pooja Temgire, Puneet Kumar

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Abstract

Introduction: Recent neuroscience breakthroughs have shed light on the sophisticated relationship between calcium channelopathies and movement disorders, exposing a previously undiscovered tale focusing on the Ryanodine Receptor (RyR) and the Sarco/Endoplasmic Reticulum Calcium ATPase (SERCA). Calcium signaling mainly orchestrates neural communication, which regulates synaptic transmission and total network activity. It has been determined that RyR play a significant role in managing neuronal functions, most notably in releasing intracellular calcium from the endoplasmic reticulum.

Areas covered: It highlights the involvement of calcium channels such as RyR and SERCA in physiological and pathophysiological conditions.

Expert opinion: Links between RyR and SERCA activity dysregulation, aberrant calcium levels, motor and cognitive dysfunction have brought attention to the importance of RyR and SERCA modulation in neurodegenerative disorders. Understanding the obscure function of these proteins will open up new therapeutic possibilities to address the underlying causes of neurodegenerative diseases. The unreported RyR and SERCA narrative broadens the understanding of calcium channelopathies in movement disorders and calls for more research into cutting-edge therapeutic approaches.

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神经退行性疾病中的钙通道病变:RyR和SERCA不为人知的故事。

最近的神经科学突破揭示了钙通道病变和运动障碍之间的复杂关系，揭示了一个以前未被发现的故事，重点是Ryanodine受体(RyR)和Sarco/内质网钙atp酶(SERCA)。钙信号主要协调神经通讯，调节突触传递和总网络活动。已经确定RyR在管理神经元功能中发挥重要作用，最显著的是从内质网释放细胞内钙。涵盖领域:它强调了钙通道如RyR和SERCA在生理和病理生理条件下的参与。专家意见:RyR和SERCA活性失调、钙水平异常、运动和认知功能障碍之间的联系使人们注意到RyR和SERCA调节在神经退行性疾病中的重要性。了解这些蛋白质的模糊功能将为解决神经退行性疾病的潜在原因开辟新的治疗可能性。未报道的RyR和SERCA叙述拓宽了对运动障碍中钙通道病变的理解，并呼吁对前沿治疗方法进行更多研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Opinion on Therapeutic Targets 医学-药学

CiteScore

8.90

自引率

1.70%

发文量

审稿时长

3 months

期刊介绍： The journal evaluates molecules, signalling pathways, receptors and other therapeutic targets and their potential as candidates for drug development. Articles in this journal focus on the molecular level and early preclinical studies. Articles should not include clinical information including specific drugs and clinical trials. The Editors welcome: Reviews covering novel disease targets at the molecular level and information on early preclinical studies and their implications for future drug development. Articles should not include clinical information including specific drugs and clinical trials. Original research papers reporting results of target selection and validation studies and basic mechanism of action studies for investigative and marketed drugs. The audience consists of scientists, managers and decision makers in the pharmaceutical industry, academic researchers working in the field of molecular medicine and others closely involved in R&D.