Clinical characteristics and outcomes of hypersensitivity pneumonitis in South Korea.

IF 3.3 3区医学 Q2 RESPIRATORY SYSTEM Therapeutic Advances in Respiratory Disease Pub Date : 2023-01-01 DOI:10.1177/17534666231212304

Sungmin Zo, Man Pyo Chung, Hak Young Yoo, Kyung Soo Lee, Joungho Han, Myung Jin Chung, Hongseok Yoo

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Abstract

Background: Hypersensitivity pneumonitis (HP) is an interstitial lung disease (ILD) that results from an immune-mediated reaction involving various antigens in susceptible individuals. However, the clinical characteristics and outcomes of HP in South Korea are not well understood.

Objectives: This study was conducted to identify the clinical characteristics and outcomes of HP in South Korea.

Design: This is a retrospective observational study investigating patients with pathologically confirmed HP at our center, along with a comprehensive review of published HP cases in the Republic of Korea.

Methods: This retrospective study analyzed 43 patients with pathologically proven HP at a single tertiary hospital in Korea between 1996 and 2020. In addition, case reports of HP published in Korea were collected. The clinical characteristics, etiologies, treatment, and outcomes of patients from our center, as well as case reports, were reviewed. Patients from our hospital were divided into fibrotic and nonfibrotic subtypes according to the ATS/JRS/ALAT guidelines.

Results: Among 43 patients with biopsy-proven HP, 12 (27.9%) and 31 (72.1%) patients were classified into the fibrotic and nonfibrotic subtypes, respectively. The fibrotic HP group was older (64.6 ± 8.5 versus 55.2 ± 8.3, p = 0.002) with less frequent complaints of fever (0% versus 45.2%, p = 0.013) compared to the nonfibrotic HP group. The most common inciting antigen was household mold (21, 48.8%), followed by inorganic substances (6, 14.0%). Inciting antigens were not identified in eight (18.6%) patients. Treatment of corticosteroids was initiated in 34 (79.1%) patients. An analysis of 46 patients from Korea by literature review demonstrated that reported cases were relatively younger and drugs were the most common etiology compared to our cohort.

Conclusion: The analysis of reported cases, as well as our cohort, showed that exposure history and clinical manifestations are heterogeneous for patients with HP in South Korea.

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韩国超敏性肺炎的临床特点和结局。

背景:超敏性肺炎(Hypersensitivity pneumonitis, HP)是一种间质性肺疾病(ILD)，由易感个体中涉及多种抗原的免疫介导反应引起。然而，在韩国，HP的临床特征和结果尚不清楚。目的:本研究旨在确定韩国HP的临床特征和预后。设计:这是一项回顾性观察性研究，调查了我们中心病理证实的HP患者，并对韩国已发表的HP病例进行了全面回顾。方法:本回顾性研究分析了1996年至2020年在韩国一家三级医院病理证实的43例HP患者。此外，还收集了国内发表的HP病例报告。我们回顾了本中心患者的临床特征、病因、治疗和预后，以及病例报告。根据ATS/JRS/ALAT指南将我院患者分为纤维化亚型和非纤维化亚型。结果:43例活检证实的HP患者中，纤维化亚型12例(27.9%)，非纤维化亚型31例(72.1%)。与非纤维化HP组相比，纤维化HP组年龄较大(64.6±8.5比55.2±8.3,p = 0.002)，发热主诉较少(0%比45.2%，p = 0.013)。最常见的诱发抗原为家用霉菌(21例，48.8%)，其次为无机物(6例，14.0%)。8例(18.6%)患者未检出刺激性抗原。34例(79.1%)患者开始使用皮质类固醇治疗。通过文献回顾对韩国46例患者的分析表明，与我们的队列相比，报告的病例相对年轻，药物是最常见的病因。结论:对报告病例的分析以及我们的队列分析表明，韩国HP患者的暴露史和临床表现是不同的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Therapeutic Advances in Respiratory Disease RESPIRATORY SYSTEM-

CiteScore

6.90

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： Therapeutic Advances in Respiratory Disease delivers the highest quality peer-reviewed articles, reviews, and scholarly comment on pioneering efforts and innovative studies across all areas of respiratory disease.