Adarsh Aratikatla, Justin Sidhu, Nicola Maffulli, Manu Gupta, Anish G Potty, Ashim Gupta
{"title":"Allogenic Umbilical Cord Tissue for Rotator Cuff Injuries.","authors":"Adarsh Aratikatla, Justin Sidhu, Nicola Maffulli, Manu Gupta, Anish G Potty, Ashim Gupta","doi":"10.1097/JSA.0000000000000369","DOIUrl":null,"url":null,"abstract":"<p><p>Highly prone to injury, the rotator cuff greatly contributes to the stability and mobility of the shoulder. Clinicians prioritize conservative treatment, resorting to surgery only when necessary, although they are hindered by inherent limitations. Biological therapies, including perinatal tissue, such as umbilical cord (UC) tissue, hold promise for treating rotator cuff injuries (RCIs) in the field of regenerative medicine. This article qualitatively presents the in vitro, preclinical, clinical, and ongoing scientific literature exploring the application of UC tissue and associated mesenchymal stem cells in the context of RCIs. Employing the \"Preferred Reporting Items for Systematic Reviews and Meta-analyses\" guidelines, a systematic review was conducted. These studies have presented substantial evidence indicating that UC tissue and UC-derived mesenchymal stem cells are safe and potentially efficacious for managing RCIs, though more adequately powered randomized controlled trials are warranted to further establish efficacy and justify clinical use.</p>","PeriodicalId":49481,"journal":{"name":"Sports Medicine and Arthroscopy Review","volume":"31 3","pages":"73-79"},"PeriodicalIF":2.5000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sports Medicine and Arthroscopy Review","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/JSA.0000000000000369","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/11/17 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"SPORT SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Highly prone to injury, the rotator cuff greatly contributes to the stability and mobility of the shoulder. Clinicians prioritize conservative treatment, resorting to surgery only when necessary, although they are hindered by inherent limitations. Biological therapies, including perinatal tissue, such as umbilical cord (UC) tissue, hold promise for treating rotator cuff injuries (RCIs) in the field of regenerative medicine. This article qualitatively presents the in vitro, preclinical, clinical, and ongoing scientific literature exploring the application of UC tissue and associated mesenchymal stem cells in the context of RCIs. Employing the "Preferred Reporting Items for Systematic Reviews and Meta-analyses" guidelines, a systematic review was conducted. These studies have presented substantial evidence indicating that UC tissue and UC-derived mesenchymal stem cells are safe and potentially efficacious for managing RCIs, though more adequately powered randomized controlled trials are warranted to further establish efficacy and justify clinical use.
期刊介绍：
Sports Medicine and Arthroscopy Review helps physicians digest the large volume of clinical literature in sports medicine and arthroscopy, identify the most important new developments, and apply new information effectively in clinical practice. Each issue is guest-edited by an acknowledged expert and focuses on a single topic or controversy. The Guest Editor invites the leading specialists on the topic to write review articles that highlight the most important advances. This unique format makes the journal more in-depth, authoritative, and practical than most publications in this field. The journal also includes dozens of full-color and black-and-white arthroscopic images and illustrations.
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