Management of systemic lupus erythematosus: A new scenario.

IF 4.5 2区 医学 Q1 RHEUMATOLOGY Best Practice & Research in Clinical Rheumatology Pub Date : 2023-12-01 Epub Date: 2023-11-17 DOI:10.1016/j.berh.2023.101895
Georgia-Savina Moysidou, Dimitrios Mastrogiorgakis, Dimitrios Boumpas, George Bertsias
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引用次数: 0

Abstract

The introduction of targeted biological agents in systemic lupus erythematosus (SLE) has created a momentum for improving overall disease management and patients' prognosis. To achieve this, a comprehensive strategy is required spanning the entire patient journey from diagnosis to prevention and management of late complications and comorbidities. In this review, we focus on four aspects that are closely linked to SLE prognosis, namely early disease recognition and treatment initiation, reduction of the cumulative glucocorticoid exposure, attainment of well-defined targets of remission and low disease activity, prevention of flares and, kidney-protective strategies with non-immune-directed agents. We review the recent literature related to these topics in conjunction with the existing treatment recommendations, highlighting areas of uncertainty and providing guidance towards facilitating the care of SLE patients.

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系统性红斑狼疮的管理:一个新的方案。
系统性红斑狼疮(SLE)靶向生物制剂的引入为改善整体疾病管理和患者预后创造了动力。为实现这一目标,需要一项全面的战略,涵盖从诊断到晚期并发症和合并症的预防和管理的整个患者旅程。在这篇综述中,我们关注与SLE预后密切相关的四个方面,即早期疾病识别和治疗开始,减少累积糖皮质激素暴露,达到明确的缓解目标和低疾病活动性,预防急性发作,以及使用非免疫定向药物的肾脏保护策略。我们回顾了最近与这些主题相关的文献,并结合现有的治疗建议,强调了不确定的领域,并为促进SLE患者的护理提供了指导。
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来源期刊
CiteScore
9.40
自引率
0.00%
发文量
43
审稿时长
27 days
期刊介绍: Evidence-based updates of best clinical practice across the spectrum of musculoskeletal conditions. Best Practice & Research: Clinical Rheumatology keeps the clinician or trainee informed of the latest developments and current recommended practice in the rapidly advancing fields of musculoskeletal conditions and science. The series provides a continuous update of current clinical practice. It is a topical serial publication that covers the spectrum of musculoskeletal conditions in a 4-year cycle. Each topic-based issue contains around 200 pages of practical, evidence-based review articles, which integrate the results from the latest original research with current clinical practice and thinking to provide a continuous update. Each issue follows a problem-orientated approach that focuses on the key questions to be addressed, clearly defining what is known and not known. The review articles seek to address the clinical issues of diagnosis, treatment and patient management. Management is described in practical terms so that it can be applied to the individual patient. The serial is aimed at the physician in both practice and training.
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