Modulation of mitogenic activity of tumor necrosis factor by interferons and dexamethasone.

Lymphokine research Pub Date : 1989-01-01

M Tsujimoto, M Sugiyama, H Adachi

引用次数: 0

Abstract

Effect of interferon (IFN)s on fibroblast growth enhancing activity of tumor necrosis factor (TNF) was examined. IFN-gamma and -beta inhibited TNF-mediated growth stimulation of FS-4 cells. IFNs also inhibited dexamethasone (DEX)-mediated amplification of mitogenic activity of TNF. Significant inhibition was still demonstrable when IFN-gamma was added 2 days after treatment with TNF. On the other hand, no mitogenic activity of TNF was observed when cells were pretreated with IFN-gamma for 6h. These results suggested that interaction between TNF and IFN-gamma might play a role in modulation of some inflammatory processes in vivo.

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干扰素和地塞米松对肿瘤坏死因子有丝分裂活性的调节。

研究了干扰素(IFN)对成纤维细胞生长的促进肿瘤坏死因子(TNF)活性的影响。ifn - γ和- β抑制tnf介导的FS-4细胞生长刺激。干扰素也抑制地塞米松(DEX)介导的肿瘤坏死因子有丝分裂活性的扩增。在TNF治疗2天后加入ifn - γ时，仍可观察到明显的抑制作用。另一方面，当细胞用ifn - γ预处理6h时，未观察到TNF的有丝分裂活性。这些结果表明TNF和ifn - γ之间的相互作用可能在体内某些炎症过程的调节中发挥作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Lymphokine research

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