[The sequence of specific immune reactions at the biliary level after oral vaccination].

Abstract

The appearance and the progression of the specific immunoreactions at biliary levels (agglutinant titre, immunoenzimatic titration of IgAGM, IgA, IgG) in rabbits treated per os from 1 to 10 times, daily or bi-weekly, with 20 and 40 milliard of inactivated bacterial antigens (E. coli, Proteus vulgaris, Staph. aureus, Str. faecalis) have been studied. The appearance of the specific biliary antibodies has been very precocious (only one day after the first administration) and the values increased progressively with the number of administrations. The posology of 40 milliard and the bi-weekly sequence of the treatments presented the highest immunoreactions. In the bile the IgA and IgG increased considerably, but the IgA have been preponderant; in the serum only the IgG presented a remarkable increase, not the IgA, that are present in very small quantity.