The plasma concentration and renal elimination of phenols in patients with chronic renal insufficiency.

Czechoslovak medicine Pub Date : 1989-01-01

O Schück, M Vidláková, J Erben, H Nádvorniková, V Teplan, V Reitschlägerová

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Abstract

The plasma concentration and renal elimination of phenols was studied in 32 individuals with various renal insufficiency (CRI) and in 30 healthy subjects. In patients with chronic renal insufficiency the increase in P phenols values correlated directly with Per and P urea. Daily urinary excretion of phenols in patients with CRI is only mildly decreased compared with that in healthy controls. Renal clearance (C phenols), 8.52 (+/- 2.69) ml/min on an average, decreases significantly in patients with CRI. While fraction excretion of phenols (FE phenols) was 9.53 (+/- 4.14) % on an average in healthy persons, patients with CRI displayed a significant increase. A significant linear correlation in the values of FE phenols and FEH2O and those of FE phenols and FE urea was documented. Our findings support the assumption that phenols are excreted by the kidney by a mechanism similar to that of urea excretion. Filtration of phenols in the glomeruli is followed, in healthy volunteers, by their significant reabsorption which is a flow-dependent process. In the residual nephrons of patients with CRI, the tubular reabsorption of phenols is decreased, a mechanism largely compensating the effect of decreased filtration of phenols on their total urinary excretion.

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慢性肾功能不全患者酚类物质的血药浓度和肾脏消除。

本文研究了32例不同肾功能不全(CRI)患者和30例健康人的血药浓度和肾内酚类物质的消除。慢性肾功能不全患者P酚值升高与Per和P尿素直接相关。与健康对照相比，CRI患者每日尿中酚类物质的排泄量仅轻度下降。CRI患者肾清除率(C酚)平均为8.52 (+/- 2.69)ml/min，显著降低。在健康人群中，酚类物质(FE酚类物质)的排泄量平均为9.53(+/- 4.14)%，而CRI患者的排泄量明显增加。结果表明，FE酚类与FEH2O、FE酚类与FE尿素呈显著的线性相关。我们的研究结果支持这样的假设，即酚类物质通过肾脏排泄的机制与尿素排泄的机制相似。在健康志愿者的肾小球中，过滤后的酚类物质会发生显著的重吸收，这是一个依赖血流的过程。在CRI患者的残留肾元中，酚类物质的小管重吸收减少，这一机制在很大程度上补偿了酚类物质过滤减少对尿总排泄的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Czechoslovak medicine

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