Thyrotoxic Periodic Paralysis: A case report

Sarah Nadeem , Abdul Aziz , Dania Ali
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Abstract

A rare complication of thyrotoxicosis among Asians is Thyrotoxic Periodic Paralysis (TPP), with an incidence of approximately 2% in patients with thyrotoxicosis from any cause. TPP is characterized by sudden onset of hypokalemia and muscle paralysis. Hypokalemia in TPP results from an intracellular shift of potassium induced by the thyroid hormone sensitization of Na+/K+–ATPase rather than depletion of total body potassium. Treatment of TPP includes correcting the underlying hyperthyroid state, prevention of potassium shift by using non-selective beta-blockade, and replacing potassium. TPP is curable once a euthyroid state is achieved. We describe here a rare case of TPP in a young Chinese man who presented with sudden bilateral lower limb weakness.

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甲状腺毒性周期性麻痹1例
亚洲甲状腺毒症的罕见并发症是甲状腺毒性周期性麻痹(TPP),在任何原因的甲状腺毒症患者中发病率约为2%。TPP的特点是突然发作的低钾血症和肌肉麻痹。低钾血症是由甲状腺激素对Na+/K+ - atp酶致敏引起的细胞内钾转移引起的,而不是全身钾的消耗。TPP的治疗包括纠正潜在的甲状腺功能亢进状态,使用非选择性β -阻断剂预防钾转移,以及替代钾。一旦达到甲状腺正常状态,TPP是可以治愈的。我们在此描述一例罕见的TPP病例,一名年轻的中国男子表现为突然的双侧下肢无力。
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来源期刊
Journal of Clinical and Translational Endocrinology: Case Reports
Journal of Clinical and Translational Endocrinology: Case Reports Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
1.10
自引率
0.00%
发文量
32
审稿时长
27 weeks
期刊介绍: The journal publishes case reports in a variety of disciplines in endocrinology, including diabetes, metabolic bone disease and osteoporosis, thyroid disease, pituitary and lipid disorders. Journal of Clinical & Translational Endocrinology Case Reports is an open access publication.
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