Evolución de los pacientes con cáncer de mama que sobreexpresan el receptor del factor de crecimiento epidérmico humano (HER2/Neu) en el Hospital del Instituto de Seguridad y Servicio Social de los Trabajadores al Servicio de los Poderes del Estado de Puebla (ISSSTEP)

Abstract

Purpose

The purpose of this review is to know the evolution of the patients who were treated in hospital ISSSTEP with breast cancer. Most of them received trastuzumab, either adjuvant or for the treatment of metastatic disease.

Methods

We take into account the patients expressed about HER2/Neu gene, either by immunohistochemistry or FISH, with the criteria of age, clinical stage, and the evolution of his illness. This review covers the year 2009 by the end of 2014.

Results

The patients with breast cancer were reported 238, of which 187 collect HER2/Neu negative, and 51 patients with HER2/Neu positive. Patients who developed metastases, either at the beginning of his illness, or as part of their recurrence were 37 in total, with 26 for the HER2/Neu negative group and 11 for the HER2/Neu positive group. The metastatic sites of HER2/Neu positive patients were: 5 in central nervous system, 5 to skin, 4 to lung, 3 to bone, and 2 to liver.

Conclusion

Our group, indicates that the most common site of metastasis is the central nervous system and skin. Based on this experience we believe that patients who over-express HER2/Neu should have baseline brain scans, and their developments as well as neurological symptoms should be closely monitored, or perform periodic scans to detect early metastasis.