Scleroglucan sustained-release oral preparations. Part I. In vitro experiments.

Drug design and delivery Pub Date : 1989-12-01
E Touitou, F Alhaique, F M Riccieri, G Riccioni, E Santucci
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Abstract

Experiments performed in vitro with tablets and capsules indicate that the fungal polysaccharide scleroglucan is suitable for the formulation of sustained-release, oral dosage forms. Delivery of model drugs from the non-disintegrating matrix was studied in solutions buffered at different pH values. The effect on drug release of drug concentration, the physico-chemical properties of the drug, and the compression force used in the preparation of the matrix are reported, and the possible mechanisms of release are discussed.

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硬葡聚糖缓释口服制剂。第一部分体外实验。
体外片剂和胶囊实验表明,该真菌多糖硬葡聚糖适合于制剂的缓释、口服剂型。在不同pH值的缓冲溶液中,研究了模型药物从非崩解基质中的递送。报道了药物浓度对药物释放的影响、药物的物理化学性质以及制备基质时所用的压缩力,并讨论了可能的释放机制。
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