{"title":"Metabolic pathways fuelling protumourigenic cancer-associated fibroblast functions","authors":"Emily J. Kay , Sara Zanivan","doi":"10.1016/j.coisb.2021.100377","DOIUrl":null,"url":null,"abstract":"<div><p>Cancer-associated fibroblasts (CAFs) play many roles in supporting tumour growth and progression, and metabolic rewiring is known to be a hallmark of CAF activation. How to effectively target CAF metabolism is still an open question, however. Recent research shows that CAFs and cancer cells engage in complex metabolic crosstalk, which may offer strategies to metabolically target both tumour and stroma. CAF metabolic rewiring also regulates intrinsic CAF protumourigenic functions, by inducing epigenetic changes to maintain CAF activation and by promoting hallmarks of CAFs such as extracellular matrix (ECM) production and immunosuppression. Finally, the emerging field of CAF subpopulations has opened up possibilities for metabolically targeting specific protumourigenic subgroups and raises new questions about how we define and target CAFs.</p></div>","PeriodicalId":37400,"journal":{"name":"Current Opinion in Systems Biology","volume":"28 ","pages":"Article 100377"},"PeriodicalIF":3.4000,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.coisb.2021.100377","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Systems Biology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2452310021000718","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 1
Abstract
Cancer-associated fibroblasts (CAFs) play many roles in supporting tumour growth and progression, and metabolic rewiring is known to be a hallmark of CAF activation. How to effectively target CAF metabolism is still an open question, however. Recent research shows that CAFs and cancer cells engage in complex metabolic crosstalk, which may offer strategies to metabolically target both tumour and stroma. CAF metabolic rewiring also regulates intrinsic CAF protumourigenic functions, by inducing epigenetic changes to maintain CAF activation and by promoting hallmarks of CAFs such as extracellular matrix (ECM) production and immunosuppression. Finally, the emerging field of CAF subpopulations has opened up possibilities for metabolically targeting specific protumourigenic subgroups and raises new questions about how we define and target CAFs.
期刊介绍：
Current Opinion in Systems Biology is a new systematic review journal that aims to provide specialists with a unique and educational platform to keep up-to-date with the expanding volume of information published in the field of Systems Biology. It publishes polished, concise and timely systematic reviews and opinion articles. In addition to describing recent trends, the authors are encouraged to give their subjective opinion on the topics discussed. As this is such a broad discipline, we have determined themed sections each of which is reviewed once a year. The following areas will be covered by Current Opinion in Systems Biology: -Genomics and Epigenomics -Gene Regulation -Metabolic Networks -Cancer and Systemic Diseases -Mathematical Modelling -Big Data Acquisition and Analysis -Systems Pharmacology and Physiology -Synthetic Biology -Stem Cells, Development, and Differentiation -Systems Biology of Mold Organisms -Systems Immunology and Host-Pathogen Interaction -Systems Ecology and Evolution
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