Observation of growth and invasiveness of human uterine cervix carcinoma cell line (CC801) in the testes of nude mice.

Abstract

A human uterine cervix carcinoma cell line (CC801) was implanted subcapsularly in the testes of nude mice and its growth and invasiveness was observed. The results showed that the taking rate of CC801 tumor cells was 70%. Two weeks after implantation, the tumor cells were surrounded by pseudocapsule and showed no invasiveness, but 4 weeks after transplantation, they began to proliferate and to penetrate the pseudocapsule. Thereafter, the tumor cells continued to invade the neighboring tissues, causing degeneration and atrophy of seminiferous tubules at later stages. After 12 weeks, the tumor tissues occupied the whole testis. The process of invasion could be divided into 5 stages: latency, proliferation, early invasion, intermediate invasion and late invasion. The rate of lymphatic metastasis was 6.6%, but no lung metastasis was found.