[Cytoprotective effect of rosaprostol during treatment with non-steroidal anti-inflammatory agents in arthrorheumatic pathologies].

M G Cataldo, L Sallì, G Scalici, A D'Aiuto, A Bongiorno, L Salerno
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Abstract

A clinico-endoscopic study has been carried out in a group of 22 patients treated with 1 g of naproxene + 2 g of rosaprostol compared in a blind situation with another group of 19 patients treated with a similar dose of naproxene + placebo in order to evaluate the cytoprotective action of rosaprostol. Analysis of the results showed a high correlation between intake of rosaprostol and low onset of algico-dyspeptic disturbances and mucosal lesions of some gravity, although the problem of the monitoring of patients undergoing long-term treatment with NSAID remains unsolved.

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[罗沙前列醇在非甾体抗炎药治疗风湿性疾病期间的细胞保护作用]。
为了评价罗沙前列醇的细胞保护作用,对22例接受1g萘普生+ 2g罗沙前列醇治疗的患者进行了一项临床内镜研究,并与另一组19例接受相似剂量萘普生+安慰剂治疗的患者进行了盲对照。分析结果显示,摄入罗沙前列醇与低发生率的藻类消化不良障碍和一定程度的粘膜病变之间存在高度相关性,尽管长期接受非甾体抗炎药治疗的患者的监测问题仍未解决。
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