Foetal and lactational exposure to alcohol increases oxidative capacity of brown adipose tissue in the rat. A possible relationship to cot death.

P Huttunen, M L Kortelainen, J Hirvonen
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Abstract

The effect was studied of chronic alcohol intake in the rat during pregnancy and lactation on the brown adipose tissue (BAT) in pups. The idea was to find a possible relationship to cot death since in some cot death victims increased amounts of BAT have been observed. Exposure to ethanol increased the relative weight of the brown adipose tissue in pups and enhanced both its total protein content and the activities of the oxidative enzymes, succinate dehydrogenase and cytochrome oxidase. In the BAT of pups sympathetic activity, as demonstrated by noradrenaline, was also increased by long-term exposure to alcohol. In theory, an increased thermogenic capacity of the BAT in the newborn together with other factors such as emotional stress and infections could lead to death from hyperthermia, in which case only non-specific morphological signs would be found in the cadaver.

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胎儿和哺乳期暴露于酒精会增加大鼠棕色脂肪组织的氧化能力。可能与婴儿猝死有关。
研究了妊娠期和哺乳期大鼠慢性酒精摄入对幼鼠棕色脂肪组织(BAT)的影响。这个想法是为了找到可能与婴儿猝死的关系,因为在一些婴儿猝死的受害者中观察到BAT含量增加。乙醇增加了幼崽棕色脂肪组织的相对重量,提高了褐脂肪组织的总蛋白质含量和氧化酶、琥珀酸脱氢酶和细胞色素氧化酶的活性。在蝙蝠幼崽的交感神经活动中,正如去甲肾上腺素所显示的那样,长期暴露于酒精中也会增加。理论上,新生儿BAT产热能力的增加,加上其他因素,如情绪压力和感染,可能导致高温致死,在这种情况下,尸体中只会发现非特异性形态学迹象。
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