Review article: is there a common principle in the development of gastrointestinal cancers? Stem cells in the origin of cancer

Alimentary Pharmacology & Therapeutics Symposium Series Pub Date : 2006-06-26 DOI:10.1111/j.1746-6342.2006.00023.x

N. A. WRIGHT

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Abstract

Summary

Background

Accumulating evidence, outlined in this review, at last provides some elucidation of the orgin of gastrointestinal epithelial tumours.

Methods

New techniques, such as following the process of crypt or gastric gland purification following mutation in genes encoded by the mitochondrial genome, have shown that mutations spead within the proliferative unit, either gastric gland or intestinal crypt, by clonal purification or monoclonal conversion. Spreading otside the crypt or gland then takes place by fission.

Results

Future research should focus on the mecanisim by which mutated stem cells colonize crypts, and on the mechanisms of crypt fission itself.

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综述文章:胃肠道癌症的发展是否有一个共同的原则?干细胞在癌症起源中的作用

背景:本文总结了越来越多的证据，最终为胃肠道上皮肿瘤的起源提供了一些解释。方法线粒体基因组编码基因突变后的隐窝或胃腺纯化等新技术表明，通过克隆纯化或单克隆转化，突变可在增殖单位(胃腺或肠隐窝)内传播。然后通过裂变扩散到隐窝或腺外。结果今后的研究重点应放在突变干细胞定植隐窝的机制和隐窝裂变本身的机制上。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Alimentary Pharmacology & Therapeutics Symposium Series

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