Effect of a moderate alcohol dose on physiological responses during rest and prolonged cycling.

IF 2.1 4区 医学 Q3 SUBSTANCE ABUSE Alcohol and alcoholism Pub Date : 2024-01-17 DOI:10.1093/alcalc/agad079
Andrew Marley, Marianna Bakali, Charlie Simpson
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Abstract

Aim: We examined the acute effects of a moderate alcohol dose (48 g) ingested before prolonged cycling on acute physiological responses in eight healthy males (mean ± SD; 23 ± 2 years; 1.77 ± 0.04 m; 75.8 ± 4.1 kg).

Methods: In a randomized order, euhydrated participants completed two experimental sessions with the sequence of 150-min seated at rest, 90-min of cycling at 50% of the maximal rate of oxygen consumption ($\dot{\textrm V}\textrm O$2max), 120-min seated at rest. Participants drank 250 mL of flavored squash with or without alcohol (vodka; ~16 g) at 10, 40, and 70 min of the initial resting phase, giving a cumulative fluid intake of 750 mL with 48 g of alcohol. Heart rate, blood glucose, breath alcohol concentration, and respiratory gasses were recorded throughout the entire trial with cumulative urine volume recorded during both rest phases.

Results: Total carbohydrate (control = 115 ± 19 g: alcohol = 119 ± 21 g; P = 0.303) and lipid (control = 17 ± 4 g: alcohol = 20 ± 7 g; P = 0.169) oxidation was similar between conditions. Average heart rate was 7% higher in the alcohol condition (control = 111 ± 12 bpm; alcohol = 119 ± 11 bpm; P = 0.003). Blood glucose concentrations were similar between conditions during (P = 0.782) and after exercise (P = 0.247). Urine output was initially increased between conditions following alcohol ingestion before diminishing (P < 0.001) with no difference in total cumulative urine output (P = 0.331).

Conclusion: Consuming an alcoholic drink containing 48 g of alcohol in the hour before moderate intensity sub-maximal aerobic exercise led to detectable increases in heart rate and rate of urine production with no effect on substrate use.

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适量酒精对休息和长时间循环期间生理反应的影响。
目的:我们研究了8名健康男性在长时间骑行前摄入适量酒精(48 g)对急性生理反应的急性影响(mean±SD;23±2年;1.77±0.04 m;75.8±4.1 kg)。方法:脱水的参与者按随机顺序完成两个实验,依次为150分钟静坐,90分钟以最大耗氧量的50% ($\dot{\textrm V}\textrm O$2max)骑行,120分钟静坐休息。参与者喝250毫升的调味南瓜,有或没有酒精(伏特加;在初始静息期的10、40和70分钟(约16 g),用48 g酒精累计摄入750 mL液体。在整个试验过程中记录心率、血糖、呼气酒精浓度和呼吸气体,并在两个休息阶段记录累积尿量。结果:总碳水化合物(对照组= 115±19 g;酒精= 119±21 g;P = 0.303)和脂质(控制= 17±4 g:酒精= 20±7 g;P = 0.169)。酒精状态下的平均心率高7%(对照组= 111±12 bpm;酒精= 119±11bpm;p = 0.003)。运动期间(P = 0.782)和运动后(P = 0.247)血糖浓度相似。结论:在中等强度次最大有氧运动前一小时饮用含48克酒精的酒精饮料,可导致心率和尿产率明显增加,但对底物的使用没有影响。
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来源期刊
Alcohol and alcoholism
Alcohol and alcoholism 医学-药物滥用
CiteScore
4.70
自引率
3.60%
发文量
62
审稿时长
4-8 weeks
期刊介绍: About the Journal Alcohol and Alcoholism publishes papers on the biomedical, psychological, and sociological aspects of alcoholism and alcohol research, provided that they make a new and significant contribution to knowledge in the field. Papers include new results obtained experimentally, descriptions of new experimental (including clinical) methods of importance to the field of alcohol research and treatment, or new interpretations of existing results. Theoretical contributions are considered equally with papers dealing with experimental work provided that such theoretical contributions are not of a largely speculative or philosophical nature.
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